ARHGAP11B
Sign in to saveAlso known as B'-T, FAM7B1, Rho GTPase activating protein 11B, GAP (1-8), ArhGAP11B and human encephalisation
ARHGAP11B is a human-specific gene that amplifies basal progenitors, controls neural progenitor proliferation, and contributes to neocortex folding. It is capable of causing neocortex folding in mice. This likely reflects a role for ARHGAP11B in development and evolutionary expansion of the human neocortex, a conclusion consistent with the finding that the gene duplication that created ARHGAP11B occurred on the human lineage after the divergence from the chimpanzee lineage but before the divergence from Neanderthals.
Gene data
ARHGAP11B- Name
- Rho GTPase activating protein 11B
- Type
- protein-coding
- Aliases
- B'-T, FAM7B1, GAP (1-8)
Predicted to enable GTPase activator activity. Involved in cerebral cortex development and negative regulation of mitochondrial membrane permeability. Acts upstream of with a positive effect on glutamine catabolic process. Located in mitochondrial matrix. [provided by Alliance of Genome Resources, Apr 2022]
via MyGene.info
Wikidata facts
Show 4 more facts
- exact match
- identifiers.org/ncbigene/89839
- genomic start
- 30624494
- genomic end
- 30649529
- cytogenetic location
- 15q13.2
Sources (3)
via Wikidata · CC0
~3 min read
Article
6 sectionsContents
- Structure
- Activity
- Function
- Human evolution
- References
- Further reading
ARHGAP11B is a human-specific gene that amplifies basal progenitors, controls neural progenitor proliferation, and contributes to neocortex folding. It is capable of causing neocortex folding in mice. This likely reflects a role for ARHGAP11B in development and evolutionary expansion of the human neocortex, a conclusion consistent with the finding that the gene duplication that created ARHGAP11B occurred on the human lineage after the divergence from the chimpanzee lineage but before the divergence from Neanderthals.
== Structure ==