ARHGAP11B
Sign in to saveAlso known as B'-T, FAM7B1, Rho GTPase activating protein 11B, GAP (1-8), ArhGAP11B and human encephalisation
ARHGAP11B is a human-specific gene that amplifies basal progenitors, controls neural progenitor proliferation, and contributes to neocortex folding. It is capable of causing neocortex folding in mice. This likely reflects a role for ARHGAP11B in development and evolutionary expansion of the human neocortex, a conclusion consistent with the finding that the gene duplication that created ARHGAP11B occurred on the human lineage after the divergence from the chimpanzee lineage but before the divergence from Neanderthals.
In the Vinony graph
Within Vinony's link graph, ARHGAP11B is referenced by 7 other articles, and connects out to PubMed, Ensembl genome database project and Wikidata.
It sits within the topics Genes on human chromosome 15 and Human evolution.
Its subject is documented across 8 Wikipedia language editions.
Gene data
ARHGAP11B- Name
- Rho GTPase activating protein 11B
- Type
- protein-coding
- Position
- 30,624,494–30,649,529 (+)
- Aliases
- B'-T, FAM7B1, GAP (1-8)
- Ensembl
- ENSG00000274734
- RefSeq RNA
- NM_001039841.3, NR_148423.2
- RefSeq protein
- NP_001034930.1
Predicted to enable GTPase activator activity. Involved in cerebral cortex development and negative regulation of mitochondrial membrane permeability. Acts upstream of with a positive effect on glutamine catabolic process. Located in mitochondrial matrix. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology
Biological process
Molecular function
Cellular component
Pathways
via MyGene.info
Gene · Ensembl
Rho GTPase activating protein 11B
- Symbol
- ARHGAP11B
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- Chr HSCHR15_4_CTG8:2,911,147-2,971,326
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 7 more facts
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/89839
- chromosome
- human chromosome 15
- genomic start
- 30624494
- genomic end
- 30649529
- cytogenetic location
- 15q13.2
- expressed in
- appendix
Sources (3)
via Wikidata · CC0
~3 min read
Encyclopedic overview
6 sectionsContents
- Structure
- Activity
- Function
- Human evolution
- References
- Further reading
ARHGAP11B is a human-specific gene that amplifies basal progenitors, controls neural progenitor proliferation, and contributes to neocortex folding. It is capable of causing neocortex folding in mice. This likely reflects a role for ARHGAP11B in development and evolutionary expansion of the human neocortex, a conclusion consistent with the finding that the gene duplication that created ARHGAP11B occurred on the human lineage after the divergence from the chimpanzee lineage but before the divergence from Neanderthals.
== Structure ==
Excerpted from Wikipedia’s “ARHGAP11B” article, available under the CC BY-SA 4.0 licence.