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armodafinil
Sign in to saveAlso known as (–)-2-[(R)-(diphenylmethyl)sulfinyl]acetamide, R-modafinil, (-)-(R)-modafinil, (R)-modafinil, (R)-(-)-modafinil, (-)-modafinil
Armodafinil, sold under the brand name Nuvigil, is a wakefulness-promoting medication that is used to treat excessive daytime sleepiness associated with obstructive sleep apnea, narcolepsy, and shift work disorder. It is also used off-label for certain other indications. The drug is taken by mouth.
Chemical data
- Formula
- C15H15NO2S
- Molecular weight
- 273.4 g/mol
- IUPAC name
- 2-[(R)-benzhydrylsulfinyl]acetamide
- SMILES
- C1=CC=C(C=C1)C(C2=CC=CC=C2)[S@](=O)CC(=O)N
- InChIKey
- YFGHCGITMMYXAQ-LJQANCHMSA-N
- XLogP
- 1.7
- Polar surface area
- 79.4 Ų
- H-bond donors
- 1
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Research
2,403 papers- Armodafinil.CNS drugs · 2009
- Armodafinil in Milk.Journal of human lactation : official journal of International Lactation Consultant Association · 2023
- Modafinil/armodafinil for excessive daytime sleepiness after traumatic brain injury: a systematic review and meta-analysis.Brain injury · 2025
- Armodafinil as a Potential Pharmacological Treatment for Attention Deficit Hyperactivity Disorder in Adults: A Review.Current neuropharmacology · 2024
- Armodafinil for excessive daytime sleepiness.Drugs of today (Barcelona, Spain : 1998) · 2008
via PubMed
~15 min read
Encyclopedic overview
28 sectionsContents
- Medical uses
- Psychiatry
- Bipolar disorder
- Schizophrenia
- Jet lag
- Attention deficit hyperactivity disorder
- Available forms
- Adverse effects
- Misuse potential
- Interactions
- Pharmacology
- Pharmacodynamics
- Pharmacokinetics
- Absorption
- Distribution
- Metabolism
- Elimination
- Chemistry
- Synthesis
- Analogues
- History
- Society and culture
- Brand names
- Legal status
- Romania
- Research
- References
- External links
Armodafinil, sold under the brand name Nuvigil, is a wakefulness-promoting medication that is used to treat excessive daytime sleepiness associated with obstructive sleep apnea, narcolepsy, and shift work disorder. It is also used off-label for certain other indications. The drug is taken by mouth.
Side effects of armodafinil include headache, nausea, dizziness, and insomnia. Armodafinil acts as a selective atypical dopamine reuptake inhibitor (DRI) and hence as an indirect dopamine receptor agonist. Nonetheless, other mechanisms might also be involved in its effects. Chemically, armodafinil is the enantiopure (R)-(–)-enantiomer of the racemic mixture modafinil (brand name Provigil). Both enantiomers of modafinil are active as DRIs and wakefulness-promoting agents, but armodafinil is more potent and has a much longer half-life and duration.
Excerpted from Wikipedia’s “armodafinil” article, available under the CC BY-SA 4.0 licence.