armodafinil
Sign in to saveArmodafinil, sold under the brand name Nuvigil, is a wakefulness-promoting medication that is used to treat excessive daytime sleepiness associated with obstructive sleep apnea, narcolepsy, and shift work disorder. It is also used off-label for certain other indications. The drug is taken by mouth.
Research
2,403 papers- Armodafinil.CNS drugs · 2009
- Armodafinil in Milk.Journal of human lactation : official journal of International Lactation Consultant Association · 2023
- Modafinil/armodafinil for excessive daytime sleepiness after traumatic brain injury: a systematic review and meta-analysis.Brain injury · 2025
- Armodafinil as a Potential Pharmacological Treatment for Attention Deficit Hyperactivity Disorder in Adults: A Review.Current neuropharmacology · 2024
- Armodafinil for excessive daytime sleepiness.Drugs of today (Barcelona, Spain : 1998) · 2008
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Article
28 sectionsContents
- Medical uses
- Psychiatry
- Bipolar disorder
- Schizophrenia
- Jet lag
- Attention deficit hyperactivity disorder
- Available forms
- Adverse effects
- Misuse potential
- Interactions
- Pharmacology
- Pharmacodynamics
- Pharmacokinetics
- Absorption
- Distribution
- Metabolism
- Elimination
- Chemistry
- Synthesis
- Analogues
- History
- Society and culture
- Brand names
- Legal status
- Romania
- Research
- References
- External links
Armodafinil, sold under the brand name Nuvigil, is a wakefulness-promoting medication that is used to treat excessive daytime sleepiness associated with obstructive sleep apnea, narcolepsy, and shift work disorder. It is also used off-label for certain other indications. The drug is taken by mouth.
Side effects of armodafinil include headache, nausea, dizziness, and insomnia. Armodafinil acts as a selective atypical dopamine reuptake inhibitor (DRI) and hence as an indirect dopamine receptor agonist. Nonetheless, other mechanisms might also be involved in its effects. Chemically, armodafinil is the enantiopure (R)-(–)-enantiomer of the racemic mixture modafinil (brand name Provigil). Both enantiomers of modafinil are active as DRIs and wakefulness-promoting agents, but armodafinil is more potent and has a much longer half-life and duration.