ASIC2

Also known as ACCN, ACCN1, ASIC2a, BNC1, BNaC1, MDEG, hBNaC1, acid sensing ion channel subunit 2

Acid-sensing ion channel 2 (ASIC2) also known as amiloride-sensitive cation channel 1, neuronal (ACCN1) or brain sodium channel 1 (BNaC1) is a protein that in humans is encoded by the ASIC2 gene. The ASIC2 gene is one of the five paralogous genes that encode proteins that form trimeric acid-sensing ion channels (ASICs) in mammals. The cDNA of this gene was first cloned in 1996. The ASIC genes have splicing variants that encode different proteins that are called isoforms.

In the Vinony graph

Within Vinony's link graph, ASIC2 is referenced by 301 other articles, and connects out to PubMed, human chromosome 17 and Ensembl genome database project.

It sits within the topics Genes on human chromosome 17 and Sodium channels.

Its subject is documented across 5 Wikipedia language editions.

Gene data

ASIC2

Name: acid sensing ion channel subunit 2
Type: protein-coding
Position: 33,013,087–34,174,964 (−)
Aliases: ACCN, ACCN1, ASIC2a, BNC1, BNaC1, MDEG, hBNaC1
Ensembl: ENSG00000108684
RefSeq RNA: NM_001094.5, NM_183377.2
RefSeq protein: NP_001085.2, NP_899233.1

This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene may play a role in neurotransmission. In addition, a heteromeric association between this member and acid-sensing (proton-gated) ion channel 3 has been observed to co-assemble into proton-gated channels sensitive to gadolinium. Alternative splicing has been observed at this locus and two variants, encoding distinct isoforms, have been identified. [provided by RefSeq, Feb 2012].