Structure via PubChem · Public domain (PubChem)
atogepant
Sign in to saveAlso known as (3S)-N-[(3S,5S,6R)-6-methyl-2-oxo-1-(2,2,2-trifluoroethyl)-5-(2,3,6-trifluorophenyl)piperidin-3-yl]-2-oxospiro[1H-pyrrolo[2,3-b]pyridine-3,6'-5,7-dihydrocyclopenta[b]pyridine]-3'-carboxamide, AGN-241689, MK-8031, Qulipta
Atogepant, sold under the brand name Qulipta among others, is a medication used to prevent migraines. It is a gepant, a calcitonin gene-related peptide receptor antagonist administered orally.
Key facts
- Drug.image
- Atogepant.svg
- Drug.image_class
- skin-invert-image
- Drug.tradename
- Qulipta, Aquipta
- Drug.MedlinePlus
- a621052
- Drug.DailyMedID
- Atogepant
- Drug.pregnancy_AU
- B3
- Drug.routes_of_administration
- By mouth
- Drug.ATC_prefix
- N02
- Drug.ATC_suffix
- CD07
- Drug.legal_AU
- S4
- Drug.legal_CA
- Rx-only
- Drug.legal_US
- Rx-only
- Drug.legal_EU
- Rx-only
- Drug.CAS_number
- 1374248-81-3
- Drug.PubChem
- 72163100
- Drug.DrugBank
- DB16098
- Drug.ChemSpiderID
- 59718640
- Drug.UNII
- 7CRV8RR151
via Wikipedia infobox
Chemical data
- Formula
- C29H23F6N5O3
- Molecular weight
- 603.5 g/mol
- IUPAC name
- (3S)-N-[(3S,5S,6R)-6-methyl-2-oxo-1-(2,2,2-trifluoroethyl)-5-(2,3,6-trifluorophenyl)piperidin-3-yl]-2-oxospiro[1H-pyrrolo[2,3-b]pyridine-3,6'-5,7-dihydrocyclopenta[b]pyridine]-3'-carboxamide
- SMILES
- C[C@@H]1[C@@H](C[C@@H](C(=O)N1CC(F)(F)F)NC(=O)C2=CC3=C(C[C@@]4(C3)C5=C(NC4=O)N=CC=C5)N=C2)C6=C(C=CC(=C6F)F)F
- InChIKey
- QIVUCLWGARAQIO-OLIXTKCUSA-N
- XLogP
- 3.4
- Polar surface area
- 104 Ų
- H-bond donors
- 2
- H-bond acceptors
- 11
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 2021
- Admin. routes
- oral
- Indications
- migraine disorder
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 603.170508916
- Said to be same as
- zavegepant
- Has use
- medication
Show 3 more facts
- isomeric SMILES
- C[C@@H]1[C@@H](C[C@@H](C(=O)N1CC(F)(F)F)NC(=O)C2=CC3=C(C[C@@]4(C3)C5=C(NC4=O)N=CC=C5)N=C2)C6=C(C=CC(=C6F)F)F
- chemical formula
- C₂₉H₂₃F₆N₅O₃
- canonical SMILES
- CC1C(CC(C(=O)N1CC(F)(F)F)NC(=O)C2=CC3=C(CC4(C3)C5=C(NC4=O)N=CC=C5)N=C2)C6=C(C=CC(=C6F)F)F
Sources (1)
via Wikidata · CC0
~3 min read
Encyclopedic overview
4 sectionsContents
- Medical uses
- History
- Research
- References
Atogepant, sold under the brand name Qulipta among others, is a medication used to prevent migraines. It is a gepant, a calcitonin gene-related peptide receptor antagonist administered orally.
The most common side effects include nausea, constipation, tiredness, somnolence (sleepiness), decreased appetite, and decreased weight.
Excerpted from Wikipedia’s “atogepant” article, available under the CC BY-SA 4.0 licence.