EntityQ221174· pop 34· linked from 1,641 articles

topiramate

Topiramate, marketed as Topamax and other brand names, is an oral medication primarily prescribed for the treatment of epilepsy and the prophylaxis of migraines. For epilepsy, this includes treatment for generalized or focal seizures. It has also been used off-label for alcohol dependence and essential tremor.

Key facts

Drug.pregnancy_AU: D
Drug.Verifiedfields: changed
Drug.Watchedfields: changed
Drug.verifiedrevid: 408971931
Drug.image: Topiramate structure.svg
Drug.image_class: skin-invert-image
Drug.width: 175
Drug.image2: Topiramate 3D.png
Drug.image_class2: bg-transparent
Drug.tradename: Topamax, Trokendi XR, Qudexy XR, others
Drug.MedlinePlus: a697012
Drug.DailyMedID: Topiramate
Drug.routes_of_administration: Oral
Drug.ATC_prefix: N03
Drug.ATC_suffix: AX11
Drug.legal_AU: S4
Drug.legal_BR: C1
Drug.legal_CA: Rx-only

via Wikipedia infobox

Research

6,484 papers

Narrative Review of Topiramate: Clinical Uses and Pharmacological Considerations.Advances in therapy · 2023
Phentermine/Topiramate: Pediatric First Approval.Paediatric drugs · 2022
Topiramate for juvenile myoclonic epilepsy.The Cochrane database of systematic reviews · 2019
Topiramate Versus Naltrexone for Alcohol Use Disorder: A Genotype-Stratified Double-Blind Randomized Controlled Trial.The American journal of psychiatry · 2024
Topiramate for Weight Management in Children With Severe Obesity.Childhood obesity (Print) · 2023

via PubMed

Article

13 sections

Contents

Medical uses
Pain
Other
Adverse effects
Frequency
Overdose
Interactions
Pharmacology
Detection in body fluids
History
Research
References
External links

Common side effects include tingling, feeling tired, loss of appetite, abdominal pain, weight loss, and decreased cognitive function such as trouble concentrating. Serious side effects may include suicidal ideation, increased ammonia levels resulting in encephalopathy, and kidney stones. Topiramate can cause birth defects, including cleft lip and palate. Risks/benefits should be carefully discussed with the full treatment team. Topiramate is considered "probably compatible" with lactation and is not contraindicated for breastfeeding, though monitoring of the infant for diarrhea or poor weight gain may be considered. Its mechanism of action is unclear.