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Structure via PubChem · Public domain (PubChem)
lomerizine
Sign in to saveAlso known as Lomerazine
Lomerizine (INN; trade name Migsis) is a diphenylpiperazine class L-type and T-type calcium channel blocker. This drug is currently used clinically for the treatment of migraines, while also being used experimentally for the treatment of glaucoma and optic nerve injury.
Chemical data
- Formula
- C27H30F2N2O3
- Molecular weight
- 468.5 g/mol
- IUPAC name
- 1-[bis(4-fluorophenyl)methyl]-4-[(2,3,4-trimethoxyphenyl)methyl]piperazine
- SMILES
- COC1=C(C(=C(C=C1)CN2CCN(CC2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F)OC)OC
- InChIKey
- JQSAYKKFZOSZGJ-UHFFFAOYSA-N
- XLogP
- 4.9
- Polar surface area
- 34.2 Ų
- H-bond donors
- 0
- H-bond acceptors
- 7
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 468.222
Show 3 more facts
- chemical formula
- C₂₇H₃₀F₂N₂O₃
- canonical SMILES
- COC1=C(C(=C(C=C1)CN2CCN(CC2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F)OC)OC
- subject has role
- calcium channel blocker
Sources (2)
via Wikidata · CC0
~6 min read
Encyclopedic overview
5 sectionsContents
- Solubility
- Mechanism of action
- Medical use
- Pharmacokinetics
- References
Lomerizine (INN; trade name Migsis) is a diphenylpiperazine class L-type and T-type calcium channel blocker. This drug is currently used clinically for the treatment of migraines, while also being used experimentally for the treatment of glaucoma and optic nerve injury.
==Solubility==
Excerpted from Wikipedia’s “lomerizine” article, available under the CC BY-SA 4.0 licence.