atosiban
Sign in to saveAtosiban, sold under the brand name Tractocile among others, is an inhibitor of the hormones oxytocin and vasopressin. It is used as an intravenous medication as a labour repressant (tocolytic) to halt premature labor. It was developed by Ferring Pharmaceuticals in Sweden and first reported in the literature in 1985. Originally marketed by Ferring Pharmaceuticals, it is licensed in proprietary and generic forms for the delay of imminent preterm birth in pregnant adult women.
Key facts
- Drug.Verifiedfields
- changed
- Drug.Watchedfields
- changed
- Drug.verifiedrevid
- 457801156
- Drug.image
- Atosiban SW.svg
- Drug.image_class
- skin-invert-image
- Drug.width
- 275
- Drug.tradename
- Tractocile, Antocin, others
- Drug.licence_EU
- yes
- Drug.routes_of_administration
- Intravenous
- Drug.ATC_prefix
- G02
- Drug.ATC_suffix
- CX01
- Drug.legal_AU
- S4
- Drug.legal_UK
- POM
- Drug.legal_EU
- Rx-only
- Drug.legal_status
- Rx-only
- Drug.CAS_number
- 90779-69-4
- Drug.PubChem
- 5311010
- Drug.IUPHAR_ligand
- 2213
via Wikipedia infobox
Research
643 papers- Atosiban versus placebo for threatened preterm birth (APOSTEL 8): a multicentre, randomised controlled trial.Lancet (London, England) · 2025
- Atosiban.Clinical obstetrics and gynecology · 1995
- Efficacy of atosiban for repeated embryo implantation failure: A systematic review and meta-analysis.Frontiers in endocrinology · 2023
- Atosiban for preterm labour.Drugs · 2004
- Atosiban improves the outcome of embryo transfer. A systematic review and meta-analysis of randomized and non-randomized trials.JBRA assisted reproduction · 2020
via PubMed
Wikidata facts
- Mass
- 993.441209
Show 5 more facts
- chemical formula
- C₄₃H₆₇N₁₁O₁₂S₂
- Commons category
- Atosiban
- isomeric SMILES
- CC[C@H](C)[C@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CSSCCC(=O)N[C@@H](C(=O)N1)CC2=CC=C(C=C2)OCC)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCCN)C(=O)NCC(=O)N)CC(=O)N)[C@@H](C)O
- defined daily dose
- 165
- canonical SMILES
- CCOc1ccc(CC2NC(=O)CCSSCC(C(=O)N3CCCC3C(=O)NC(CCCN)C(=O)NCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(C(C)O)NC(=O)C(C(C)CC)NC2=O)cc1
Sources (2)
via Wikidata · CC0
~7 min read
Article
13 sectionsContents
- Medical uses
- Pharmacology
- Mechanism of action
- Other uses
- Atosiban use after assisted reproduction
- Pharmacovigilance
- Regulatory affairs
- Systematic reviews
- Clinical trials
- Atosiban vs. nifedipine
- Atosiban vs. ritodrine
- References
- External links
Atosiban, sold under the brand name Tractocile among others, is an inhibitor of the hormones oxytocin and vasopressin. It is used as an intravenous medication as a labour repressant (tocolytic) to halt premature labor. It was developed by Ferring Pharmaceuticals in Sweden and first reported in the literature in 1985. Originally marketed by Ferring Pharmaceuticals, it is licensed in proprietary and generic forms for the delay of imminent preterm birth in pregnant adult women.
The most commonly reported side effect is nausea.