azapropazone

Also known as apazone

Azapropazone is a nonsteroidal anti-inflammatory drug (NSAID). It is manufactured by Goldshield under the tradename Rheumox.

Chemical data

Formula: C16H20N4O2
Molecular weight: 300.36 g/mol
IUPAC name: 5-(dimethylamino)-9-methyl-2-propylpyrazolo[1,2-a][1,2,4]benzotriazine-1,3-dione
SMILES: CCCC1C(=O)N2C3=C(C=CC(=C3)C)N=C(N2C1=O)N(C)C
InChIKey: MPHPHYZQRGLTBO-UHFFFAOYSA-N
XLogP: 4
Polar surface area: 56.2 Å²
H-bond donors: 0
H-bond acceptors: 3
Formal charge: 0

via PubChem

Drug data · ChEMBL

Max clinical phase: Phase 2
Molecule type: Small molecule
Indications: rheumatic disease

via ChEMBL · EBI

Research

252 papers

Azapropazone - its place in the management of rheumatoid conditions.Current medical research and opinion · 1976
The pharmacology and pharmacokinetics of azapropazone - a review.Current medical research and opinion · 1976
The amphiprotic character of azapropazone and its relevance to the gastric mucosa.Archives of toxicology · 1990
Azapropazone in aspirin intolerance.Allergy · 1999
Apazone.2006

via PubMed

Wikidata facts

Subclass of: chemical compound
Mass: 300.15862587999993
Has use: medication

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Commons category: Azapropazone
chemical formula: C₁₆H₁₈N₄O₂
defined daily dose: 0.75
canonical SMILES: CCCC1C(=O)N2c3cc(ccc3N=C(N2C1=O)N(C)C)C

Sources (3)

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Encyclopedic overview

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Contents

References

Azapropazone is a nonsteroidal anti-inflammatory drug (NSAID). It is manufactured by Goldshield under the tradename Rheumox.

It was available in the UK as a prescription-only drug, with restrictions due to certain contra-indications and side-effects. Azopropazone has now been discontinued in the British National Formulary.

Excerpted from Wikipedia’s “azapropazone” article, available under the CC BY-SA 4.0 licence.

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