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EntityQ4832281· pop 6· linked from 6 articles

azaserine

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Azaserine is a naturally occurring toxic serine derivative diazo compound with antineoplastic and antibiotic properties deriving from its action as a purinergic antagonist and structural similarity to glutamine. Azaserine acts by competitively inhibiting glutamine amidotransferase, a key enzyme responsible for glutamine metabolism.

Research

859 papers

Azaserine.Antibiotics and chemotherapy · 1971
Azaserine.IARC monographs on the evaluation of the carcinogenic risk of chemicals to man · 1976
Azaserine, DON, and azotomycin: three diazo analogs of L-glutamine with clinical antitumor activity.Cancer treatment reports · 1979
Azaserine: microbiological studies.Antibiotics & chemotherapy (Northfield, Ill.) · 1954
Discovery of the Azaserine Biosynthetic Pathway Uncovers a Biological Route for α-Diazoester Production.Angewandte Chemie (International ed. in English) · 2023

Wikidata facts

Mass: 173.043655704

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chemical formula: C₅H₇N₃O₄
canonical SMILES: C(C(C(=O)O)N)OC(=O)C=[N+]=[N-]
isomeric SMILES: C([C@@H](C(=O)O)N)OC(=O)C=[N+]=[N-]

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Article

3 sections

Contents

Mechanism of Action
Properties
References

Azaserine is a naturally occurring toxic serine derivative diazo compound with antineoplastic and antibiotic properties deriving from its action as a purinergic antagonist and structural similarity to glutamine. Azaserine acts by competitively inhibiting glutamine amidotransferase, a key enzyme responsible for glutamine metabolism.

== Mechanism of Action ==

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Antineoplastic drugs Chemical pages without DrugBank identifier Diazo compounds Drugboxes which contain changes to verified fields Drugboxes which contain changes to watched fields Drugs not assigned an ATC code Drugs with no legal status ECHA InfoCard ID from Wikidata