Structure via PubChem · Public domain (PubChem)
thonzylamine
Sign in to saveAlso known as neohetramine
Thonzylamine (or neohetramine) is an antihistamine and anticholinergic used as an antipruritic. ==Synthesis== thumb|center|400px|Thonzylamine synthesis: H. L. Friedman and A, V. Tolstouhov, (1949).
Chemical data
- Formula
- C16H22N4O
- Molecular weight
- 286.37 g/mol
- IUPAC name
- N'-[(4-methoxyphenyl)methyl]-N,N-dimethyl-N'-pyrimidin-2-ylethane-1,2-diamine
- SMILES
- CN(C)CCN(CC1=CC=C(C=C1)OC)C2=NC=CC=N2
- InChIKey
- GULNIHOSWFYMRN-UHFFFAOYSA-N
- XLogP
- 2.6
- Polar surface area
- 41.5 Ų
- H-bond donors
- 0
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
- Indications
- Pruritus, Nasal congestion, allergic disease
via ChEMBL · EBI
Research
27 papers- Sensitive spectrofluorimetric and spectrophotometric methods for the determination of thonzylamine hydrochloride in pharmaceutical preparations based on coupling with dimethylbarbituric acid in presence of dicyclohexylcarbodiimide.Journal of pharmaceutical and biomedical analysis · 2000
- Substituted ethylenediamines related to thonzylamine.Archives internationales de pharmacodynamie et de therapie · 1960
- Further studies on thonzylamine in treatment of experimental tuberculosis.Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) · 1951
- Effect of an antihistaminic drug (thonzylamine) on uterine contractility.Journal of the American Medical Women's Association · 1954
- The alleged sedative effect of thonzylamine hydrochloride (neoheteramine).The Journal of laboratory and clinical medicine · 1951
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 286.179
- Has use
- medication
Show 4 more facts
- chemical formula
- C₁₆H₂₂N₄O
- subject has role
- histamine antagonist
- canonical SMILES
- CN(C)CCN(CC1=CC=C(C=C1)OC)C2=NC=CC=N2
- Commons category
- Thonzylamine
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- Synthesis
- See also
- References
Thonzylamine (or neohetramine) is an antihistamine and anticholinergic used as an antipruritic. ==Synthesis== thumb|center|400px|Thonzylamine synthesis: H. L. Friedman and A, V. Tolstouhov, (1949).
== See also == Zolamine
Excerpted from Wikipedia’s “thonzylamine” article, available under the CC BY-SA 4.0 licence.
Gallery (2)
Available in 9 languages
via Wikidata sitelinks · CC0