azatadine
Sign in to saveAlso known as Optimine®, SCH-10649, 11-(1-Methyl-4-piperidinylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine, 6,11-Dihydro-11-(1-methyl-4-piperidylidene)-5H-benzo(5,6)cyclohepta(1,2-b)pyridine, Azatadina, Azatadinum, Azatadin
Azatadine (Optimine) is a first-generation antihistamine and anticholinergic drug that was synthesized in 1963 by Schering-Plough, a former American pharmaceutical company. It is a nitrogen analog of cyproheptadine.
Research
79 papers- Azatadine.2006
- Preclinical Screening Platform Identifies Azatadine-Dimaleate as a Potent Repurposed Therapeutic Against SARS-CoV-2 Infection.Journal of medical virology · 2025
- Azatadine maleate/pseudoephedrine sulfate repetabs versus placebo in the treatment of severe perennial allergic rhinitis.The Journal of international medical research · 1980
- Azatadine maleate in perennial allergic rhinitis: effects on clinical symptoms and choice reaction time.British journal of clinical pharmacology · 1980
- Azatadine (optimine)--a new antihistamine.The Medical letter on drugs and therapeutics · 1977
via PubMed
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Encyclopedic overview
6 sectionsContents
- Pharmacology
- Field of application
- Mechanism of action
- Synthesis
- See also
- References
Azatadine (Optimine) is a first-generation antihistamine and anticholinergic drug that was synthesized in 1963 by Schering-Plough, a former American pharmaceutical company. It is a nitrogen analog of cyproheptadine.
It was patented in 1967. It has been succeeded by both loratadine and desloratadine. and marketing approvals have been widely withdrawn. == Pharmacology == Azatadine exhibits potent antihistamine, anticholinergic, antiserotonin, and antianaphylactic properties. Its anticholinergic potency is one-third that of atropine and equivalent to that of promethazine and cyproheptadine. Azatadine is among the more potent antianaphylactic agents.
Excerpted from Wikipedia’s “azatadine” article, available under the CC BY-SA 4.0 licence.