basiliximab
Sign in to saveAlso known as CHI621, SDZ-CHI-621, CHI-621, chimeric mouse-human antiCD25, Ig gamma-1 chain C region
Basiliximab, sold under the brand name Simulect, is a monoclonal antibody used to prevent rejection in kidney transplants. It is a chimeric mouse-human monoclonal antibody to the α chain (CD25) of the IL-2 receptor of T cells. It is used in combination with other medicines used to prevent organ rejection.
Key facts
- Drug.Verifiedfields
- changed
- Drug.verifiedrevid
- 459525440
- Drug.type
- mab
- Drug.mab_type
- mab
- Drug.source
- xi/o
- Drug.target
- CD25
- Drug.tradename
- Simulect
- Drug.MedlinePlus
- a612013
- Drug.licence_EU
- yes
- Drug.DailyMedID
- Basiliximab
- Drug.pregnancy_AU
- D
- Drug.routes_of_administration
- Intravenous
- Drug.class
- Immunosuppressants
- Drug.ATC_prefix
- L04
- Drug.ATC_suffix
- AC02
- Drug.legal_US
- Rx-only
- Drug.legal_EU
- Rx-only
- Drug.legal_status
- Rx-only
via Wikipedia infobox
Research
1,835 papers- Basiliximab.Drugs · 1999
- Basiliximab application on liver recipients: a meta-analysis of randomized controlled trials.Hepatobiliary & pancreatic diseases international : HBPD INT · 2017
- Basiliximab: a review of its use as induction therapy in renal transplantation.Drugs · 2003
- Treatment Options in Refractory Autoimmune Encephalitis.CNS drugs · 2022
- Basiliximab or antithymocyte globulin for induction therapy in kidney transplantation: a meta-analysis.Transplantation proceedings · 2010
via PubMed
~3 min read
Encyclopedic overview
5 sectionsContents
- Medical uses
- Mechanism of action
- Chemistry
- History
- References
Basiliximab, sold under the brand name Simulect, is a monoclonal antibody used to prevent rejection in kidney transplants. It is a chimeric mouse-human monoclonal antibody to the α chain (CD25) of the IL-2 receptor of T cells. It is used in combination with other medicines used to prevent organ rejection.
The most common side effects (seen in more than 20% of patients) include constipation, urinary tract infections (infection of the structures that carry urine), pain, nausea (feeling sick), peripheral oedema (swelling), hypertension (high blood pressure), anemia (low red blood cell counts), headache, hyperkalaemia (high blood potassium levels), hypercholesterolaemia (high blood cholesterol levels), surgical wound complication, weight increase, increased serum creatinine (a marker of kidney problems), hypophosphataemia (low blood phosphate levels), diarrhea and upper respiratory tract infection (colds).
Excerpted from Wikipedia’s “basiliximab” article, available under the CC BY-SA 4.0 licence.