buserelina

Also known as buserelin acetate, HOE 766, HOE 766A, ICI 123215, Metrelef®, Suprefact®

farmaco

Chemical data

Formula: C60H86N16O13
Molecular weight: 1239.4 g/mol
IUPAC name: (2S)-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-5-(diaminomethylideneamino)-1-[(2S)-2-(ethylcarbamoyl)pyrrolidin-1-yl]-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-[(2-methylpropan-2-yl)oxy]-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide

via PubChem

Drug data · ChEMBL

Max clinical phase: Approved
Molecule type: Protein
Indications: neoplasm, infertility, prostate cancer, prostate adenocarcinoma

via ChEMBL · EBI

Research

2,571 papers

Buserelin. A review of its pharmacodynamic and pharmacokinetic properties, and clinical profile.Drugs · 1990
[Buserelin].Deutsche medizinische Wochenschrift (1946) · 1994
Buserelin in the treatment of prostatic cancer.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 1989
Buserelin Promotes the Differentiation and Function of Macrophage-Colony-Stimulating Factor-Producing T Helper Cells.Immunological investigations · 2025
Buserelin Inhibits the Immunosuppressive Activity of Regulatory T Cells through the Protein Kinase A Signaling in a Central Precocious Puberty Model.Immunological investigations · 2022

via PubMed

Wikidata facts

Mass: 1238.656027
Has use: medication

Show 5 more facts

chemical formula: C₆₀H₈₆N₁₆O₁₃
canonical SMILES: CCNC(=O)C1CCCN1C(=O)C(CCCN=C(N)N)NC(=O)C(CC(C)C)NC(=O)C(COC(C)(C)C)NC(=O)C(CC2=CC=C(C=C2)O)NC(=O)C(CO)NC(=O)C(CC3=CNC4=CC=CC=C43)NC(=O)C(CC5=CN=CN5)NC(=O)C6CCC(=O)N6
isomeric SMILES: CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](COC(C)(C)C)NC(=O)[C@H](CC2=CC=C(C=C2)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC3=CNC4=CC=CC=C43)NC(=O)[C@H](CC5=CN=CN5)NC(=O)[C@@H]6CCC(=O)N6
defined daily dose: 1.5
has characteristic: biopharmaceutical

Sources (3)

via Wikidata · CC0

Article · Italiano

La buserelina è un ormone di rilascio delle gonadotropine ed è un agonista del GnRH. Il buserelin acetato è commercializzato da Sanofi-Aventis con il marchio Suprefact ma è anche disponibile il generico.

Abstract from DBpedia / Wikipedia · CC BY-SA

Available in 11 languages

via Wikidata sitelinks · CC0