Buserelin

Also known as buserelin acetate, HOE 766, HOE 766A, ICI 123215, Metrelef®, Suprefact®

Buserelin, sold under the brand name Suprefact among others, is a medication which is used primarily in the treatment of prostate cancer and endometriosis. It is also used for other indications such as the treatment of premenopausal breast cancer, uterine fibroids, and early puberty, in assisted reproduction for female infertility, and as a part of transgender hormone therapy. In addition, buserelin is used in veterinary medicine. The medication is typically used as a nasal spray three times per day, but is also available for use as a solution or implant for injection into fat.

Chemical data

Formula: C60H86N16O13
Molecular weight: 1239.4 g/mol
IUPAC name: (2S)-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-5-(diaminomethylideneamino)-1-[(2S)-2-(ethylcarbamoyl)pyrrolidin-1-yl]-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-[(2-methylpropan-2-yl)oxy]-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide

via PubChem

Drug data · ChEMBL

Max clinical phase: Approved
Molecule type: Protein
Indications: neoplasm, infertility, prostate cancer, prostate adenocarcinoma

via ChEMBL · EBI

Research

2,571 papers

Buserelin. A review of its pharmacodynamic and pharmacokinetic properties, and clinical profile.Drugs · 1990
[Buserelin].Deutsche medizinische Wochenschrift (1946) · 1994
Buserelin in the treatment of prostatic cancer.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 1989
Buserelin Promotes the Differentiation and Function of Macrophage-Colony-Stimulating Factor-Producing T Helper Cells.Immunological investigations · 2025
Buserelin Inhibits the Immunosuppressive Activity of Regulatory T Cells through the Protein Kinase A Signaling in a Central Precocious Puberty Model.Immunological investigations · 2022

via PubMed

Wikidata facts

Mass: 1238.656027
Has use: medication

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chemical formula: C₆₀H₈₆N₁₆O₁₃
canonical SMILES: CCNC(=O)C1CCCN1C(=O)C(CCCN=C(N)N)NC(=O)C(CC(C)C)NC(=O)C(COC(C)(C)C)NC(=O)C(CC2=CC=C(C=C2)O)NC(=O)C(CO)NC(=O)C(CC3=CNC4=CC=CC=C43)NC(=O)C(CC5=CN=CN5)NC(=O)C6CCC(=O)N6
isomeric SMILES: CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](COC(C)(C)C)NC(=O)[C@H](CC2=CC=C(C=C2)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC3=CNC4=CC=CC=C43)NC(=O)[C@H](CC5=CN=CN5)NC(=O)[C@@H]6CCC(=O)N6
defined daily dose: 1.5
has characteristic: biopharmaceutical

Sources (3)

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Available in 11 languages

via Wikidata sitelinks · CC0