butacaine
Sign in to saveButacaine is a white crystalline ester used as a local anesthetic. It was first marketed in the 1920s.
Research
55 papers- [Effect of procaine, nicotinoylprocaine and butacaine on mammalian cells in culture].Arzneimittel-Forschung · 1984
- Phospholipids as ionophores.The Journal of biological chemistry · 1976
- [Dimorphism of butacaine sulfate].Arzneimittel-Forschung · 1974
- Inhibition by local anaesthetics of adenine nucleotide translocation in rat liver mitochondria.The Biochemical journal · 1974
- The effect of butacaine on adenine nucleotide binding and translocation in rat liver mitochondria.The Biochemical journal · 1975
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Encyclopedic overview
3 sectionsContents
- Synthesis
- See also
- References
Butacaine is a white crystalline ester used as a local anesthetic. It was first marketed in the 1920s.
==Synthesis== The addition of metallic sodium to a mixture of allyl alcohol (1) and dibutylamine (2) gives the conjugate addition product 3-dibutylamino-1-propanol (3). Reaction of this intermediate with p-nitrobenzoyl chloride (4) gives the ester 5. A Béchamp reduction of the nitro group completes the synthesis of butacaine (6). thumb|500px|center|Synthesis of butacaine
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