C1GALT1
Sign in to saveAlso known as C1GALT, T-synthase, core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1
Core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1, also known as C1GALT1, is an enzyme which in humans is encoded by the C1GALT1 gene.
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Within Vinony's link graph, C1GALT1 is referenced by 496 other articles, and connects out to glucuronosyltransferase, human chromosome 7 and carbohydrate.
It is catalogued under topics including Blood antigen systems, Genes on human chromosome 7 and Protein pages needing a picture.
Its subject is documented across 5 Wikipedia language editions.
Gene data
C1GALT1- Name
- core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1
- Type
- protein-coding
- Position
- 7,156,934–7,259,333 (+)
- Aliases
- C1GALT, T-synthase
- Ensembl
- ENSG00000106392
- RefSeq RNA
- NM_020156.5, XM_011515456.3, XM_017012442.2, XM_017012444.2, XM_017012445.2
- RefSeq protein
- NP_064541.1, XP_011513758.1, XP_016867931.1, XP_016867933.1, XP_016867934.1
The protein encoded by this gene generates the common core 1 O-glycan structure, Gal-beta-1-3GalNAc-R, by the transfer of Gal from UDP-Gal to GalNAc-alpha-1-R. Core 1 is a precursor for many extended mucin-type O-glycans on cell surface and secreted glycoproteins. Studies in mice suggest that this gene plays a key role in thrombopoiesis and kidney homeostasis.[provided by RefSeq, Sep 2010].
Gene Ontology
Biological process
Molecular function
Cellular component
Pathways
via MyGene.info
Gene · Ensembl
core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1
- Symbol
- C1GALT1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 7:7,156,934-7,259,333
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 9 more facts
- found in taxon
- Homo sapiens
- HomoloGene ID
- 10599
- chromosome
- human chromosome 7
- genetic association
- multiple sclerosis
- exact match
- identifiers.org/ncbigene/56913
- genomic end
- 7248616
- genomic start
- 7196565
- cytogenetic location
- 7p22.1-p21.3
- expressed in
- gonad
via Wikidata · CC0
~1 min read
Encyclopedic overview
4 sectionsContents
- Function
- Clinical significance
- See also
- References
Core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1, also known as C1GALT1, is an enzyme which in humans is encoded by the C1GALT1 gene.
==Function== The common core 1 O-glycan structure Gal-beta-1-3GalNAc-R is a precursor for many extended mucin-type O-glycan structures in animal cell surface and secreted glycoproteins. Core 1 is synthesized by the transfer of Gal from UDP-Gal to GalNAc-alpha-1-R by core 1 beta-3-galactosyltransferase (C1GALT1).
Excerpted from Wikipedia’s “C1GALT1” article, available under the CC BY-SA 4.0 licence.