Cabergolin

Key facts

Drug.Verifiedfields

changed

Drug.Watchedfields

changed

Drug.verifiedrevid

477165198

Drug.image

Cabergoline Skeletal.png

Drug.image_class

skin-invert-image

Drug.width

268

Drug.image2

Cabergoline_3D_Xtal_ballandstick.png

Drug.image_class2

bg-transparent

Drug.width2

260

Drug.tradename

Dostinex, others

Drug.DailyMedID

Cabergoline

Drug.routes_of_administration

Oral

Drug.ATC_prefix

G02

Drug.ATC_suffix

CB03

Drug.legal_AU

S4

Drug.legal_US

Rx-only

Drug.bioavailability

50–80%

Drug.protein_bound

Moderately bound (40–42%); concentration-independent

via Wikipedia infobox

Chemical data

Formula

C26H37N5O2

Molecular weight

451.6 g/mol

IUPAC name

(6aR,9R,10aR)-N-[3-(dimethylamino)propyl]-N-(ethylcarbamoyl)-7-prop-2-enyl-6,6a,8,9,10,10a-hexahydro-4H-indolo[4,3-fg]quinoline-9-carboxamide

SMILES

CCNC(=O)N(CCCN(C)C)C(=O)[C@@H]1C[C@H]2[C@@H](CC3=CNC4=CC=CC2=C34)N(C1)CC=C

InChIKey

KORNTPPJEAJQIU-KJXAQDMKSA-N

XLogP

3.4

Polar surface area

71.7 Ų

H-bond donors

2

H-bond acceptors

4

Formal charge

0

via PubChem

Drug data · ChEMBL

Max clinical phase

Approved

Molecule type

Small molecule

First approval

1996

Admin. routes

oral

Indications

infertility, restless legs syndrome, cocaine dependence, obesity

via ChEMBL · EBI

• Cabergoline in acromegaly.Pituitary · 2017
• Cabergoline for Lactation Inhibition After Second-Trimester Abortion or Pregnancy Loss: A Randomized Controlled Trial.Obstetrics and gynecology · 2023
• Cabergoline Use and Pregnancy Outcomes: A Systematic Review.Birth defects research · 2025
• Cabergoline: a review of its use in the inhibition of lactation for women living with HIV.Journal of the International AIDS Society · 2019
• Pituitary acting drugs: cabergoline and pasireotide.Pituitary · 2022

via PubMed

Wikidata facts

Mass

451.294725

Has use

medication

via Wikidata · CC0