alpha-catenin
Sign in to saveAlso known as Alpha_catenin, IPR001033, Alpha catenin
α-Catenin (alpha-catenin) functions as the primary protein link between cadherins and the actin cytoskeleton. It has been reported that the actin binding proteins vinculin and α-actinin can bind to alpha-catenin. It has been suggested that alpha-catenin does not bind with high affinity to both actin filaments and the E-cadherin-beta-catenin complex at the same time. It has been observed that when α-catenin is not in a molecular complex with β-catenin, it dimerizes and functions to regulate actin filament assembly, possibly by competing with Arp2/3 protein. However, a protein complex including
Research
7,293 papers- Alpha-catenin: at the junction of intercellular adhesion and actin dynamics.Nature reviews. Molecular cell biology · 2004
- Biochemical and structural analysis of alpha-catenin in cell-cell contacts.Biochemical Society transactions · 2008
- Cinderella no longer: alpha-catenin steps out of cadherin's shadow.Journal of cell science · 2006
- Molecular mechanism for direct actin force-sensing by α-catenin.eLife · 2020
- Appropriate tension sensitivity of α-catenin ensures rounding morphogenesis of epithelial spheroids.Cell structure and function · 2022
via PubMed
~16 min read
Encyclopedic overview
15 sectionsContents
- Types
- History
- Current understanding of α-catenin's structure and model
- α-Catenin: Beyond cell adhesion
- Modulation of actin and tissue organization
- First insights into extra-junctional roles
- Cell Migration
- Implications in cell signaling
- Transcriptional Modulation
- Function in development across species
- Evolutionary aspects of α-catenin
- See also
- References
- External links
- References for History Onwards
α-Catenin (alpha-catenin) functions as the primary protein link between cadherins and the actin cytoskeleton. It has been reported that the actin binding proteins vinculin and α-actinin can bind to alpha-catenin. It has been suggested that alpha-catenin does not bind with high affinity to both actin filaments and the E-cadherin-beta-catenin complex at the same time. It has been observed that when α-catenin is not in a molecular complex with β-catenin, it dimerizes and functions to regulate actin filament assembly, possibly by competing with Arp2/3 protein. However, a protein complex including a cadherin, actin, β-catenin and α-catenin has not been isolated.
The amino acid sequence of α-catenin has sequence similarity to that of vinculin.
Excerpted from Wikipedia’s “alpha-catenin” article, available under the CC BY-SA 4.0 licence.