CD28
Sign in to saveAlso known as T-cell-specific surface glycoprotein CD28, CD28 antigen, TP44, CD28 Antigens
CD28 (cluster of differentiation 28) is a protein expressed on T cells that provides essential co-stimulatory signals required for T cell activation and survival. When T cells are stimulated through CD28 in conjunction with the T-cell receptor (TCR), it enhances the production of various interleukins, particularly IL-6. CD28 serves as a receptor for CD80 (B7.1) and CD86 (B7.2), proteins found on antigen-presenting cells (APCs).
Protein · UniProt
T-cell-specific surface glycoprotein CD28
- Gene
- CD28
- Organism
- Homo sapiens (Human)
- Length
- 220 aa
- Molecular mass
- 25,066 Da
- Evidence
- 1: Evidence at protein level
Receptor that plays a role in T-cell activation, proliferation, survival and the maintenance of immune homeostasis (PubMed:1650475, PubMed:7568038). Functions not only as an amplifier of TCR signals but delivers unique signals that control intracellular biochemical events that alter the gene expression program of T-cells (PubMed:24665965). Stimulation upon engagement of its cognate ligands CD80 or CD86 increases proliferation and expression of various cytokines in particular IL2 production in both CD4(+) and CD8(+) T-cell subsets (PubMed:12196291, PubMed:1650475, PubMed:35397202). Mechanist…
Swiss-Prot (reviewed) · via UniProt