CD4-Rezeptor

Also known as CD4 Antigens, T-cell surface antigen T4/Leu-3, CD4 receptor, CD4 antigen (p55), T-cell surface glycoprotein CD4, CD4, CD4 protein

Protein

Key facts

Protein family.Symbol: CD4-extrcel
Protein family.Name: CD4, Cluster of differentiation 4, extracellular
Protein family.image: PDB 1wip EBI.jpg
Protein family.caption: structure of T cell surface glycoprotein cd4, monoclinic crystal form
Protein family.Pfam: PF09191
Protein family.InterPro: IPR015274
Protein family.SCOP: 1cid
Protein family.OPM family: 193
Protein family.OPM protein: 2klu
Protein family.CDD: cd07695
Protein family.Membranome family: 27

via Wikipedia infobox

Protein · UniProt

T-cell surface glycoprotein CD4

Gene: CD4
Organism: Homo sapiens (Human)
Length: 458 aa
Molecular mass: 51,111 Da
Evidence: 1: Evidence at protein level

Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 …

3D-structureAdaptive immunityCell membraneDirect protein sequencingDisulfide bondGlycoproteinHost cell receptor for virus entryHost-virus interaction

View on UniProt →

Swiss-Prot (reviewed) · via UniProt

Clinical Trials

1 registered

PHASE1/PHASE2RECRUITING
CAR-T Cells for HIV InfectionSteven Deeks · NCT04648046

via ClinicalTrials.gov

Wikidata facts

Instance of: protein

Show 4 more facts

exact match: purl.uniprot.org/uniprot/P01730
cell component: membrane raft
Commons category: CD4
found in taxon: Homo sapiens

Sources (3)

via Wikidata · CC0

Article · Deutsch

Der CD4-Rezeptor oder einfach nur CD4 (cluster of differentiation 4) ist ein Glykoprotein, das an der Oberfläche von Zellen des Immunsystems (T-Helferzellen, Monocyten und Makrophagen) vorkommt. Tests, die die Anzahl von Zellen bestimmen, die dieses Molekül tragen, geben einen Einblick in den Zustand des Immunsystems. Bei einer Infektion mit HI-Virus verringert sich nach gewisser Zeit die Anzahl CD4-tragender Immunzellen. Beim Infektionsprozess ist das CD4-Molekül eine der Andockstellen für das HI-Virus.

Abstract from DBpedia / Wikipedia · CC BY-SA