CD4

Also known as CD4 Antigens, T-cell surface antigen T4/Leu-3, CD4 receptor, CD4 antigen (p55), T-cell surface glycoprotein CD4, CD4 protein

thumb|Image of CD4 co-receptor binding to MHC (Major Histocompatibility Complex) non-polymorphic region.

Key facts

Protein family.Symbol: CD4-extrcel
Protein family.Name: CD4, Cluster of differentiation 4, extracellular
Protein family.image: PDB 1wip EBI.jpg
Protein family.caption: structure of T cell surface glycoprotein cd4, monoclinic crystal form
Protein family.Pfam: PF09191
Protein family.InterPro: IPR015274
Protein family.SCOP: 1cid
Protein family.OPM family: 193
Protein family.OPM protein: 2klu
Protein family.CDD: cd07695
Protein family.Membranome family: 27

via Wikipedia infobox

Protein · UniProt

T-cell surface glycoprotein CD4

Gene: CD4
Organism: Homo sapiens (Human)
Length: 458 aa
Molecular mass: 51,111 Da
Evidence: 1: Evidence at protein level

Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 …

3D-structureAdaptive immunityCell membraneDirect protein sequencingDisulfide bondGlycoproteinHost cell receptor for virus entryHost-virus interaction

View on UniProt →

Swiss-Prot (reviewed) · via UniProt