Also known as CD47, ինտեգրինի հետ կապված ազդանշանային փոխարկիչ, CD47 գլիկոպրոտեին, հակածին մակերեսային որոշիչ սպիտակուց OA3, CD47 հակածին (Rh-կապված հակածին, ինտեգրին-կապված ազդանշանային տվիչ), լեյկոցիտային մակերեսային հակածին CD47, Rh-կապված անտիգեն, ինտեգրինի հետ կապված սպիտակուց
CD47 (Cluster of Differentiation 47) also known as integrin associated protein (IAP) is a transmembrane protein that in humans is encoded by the CD47 gene. CD47 belongs to the immunoglobulin superfamily and partners with membrane integrins and also binds the ligands thrombospondin 1 (TSP-1) and signal-regulatory protein alpha (SIRPα). CD-47 acts as a ''don't eat me'' signal to macrophages of the immune system which has made it a potential therapeutic target in some cancers, and more recently, for the treatment of pulmonary fibrosis.
via PubMed
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CD47 (Cluster of Differentiation 47) also known as integrin associated protein (IAP) is a transmembrane protein that in humans is encoded by the CD47 gene. CD47 belongs to the immunoglobulin superfamily and partners with membrane integrins and also binds the ligands thrombospondin 1 (TSP-1) and signal-regulatory protein alpha (SIRPα). CD-47 acts as a ''don't eat me'' signal to macrophages of the immune system which has made it a potential therapeutic target in some cancers, and more recently, for the treatment of pulmonary fibrosis.
CD47 is involved in a range of cellular processes, including apoptosis, proliferation, adhesion, and migration. Furthermore, it plays a role in insulin secretion, as well as immune and angiogenic responses. CD47 is ubiquitously expressed in human cells and has been found to be overexpressed in many different tumor cells. Expression in equine cutaneous tumors has been reported as well.
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Discovered by embedding cosine similarity (sentence-transformers MiniLM, 384-dim).