CD80 molecule
Sign in to saveAlso known as B7, BB1, CD80 antigen (CD28 antigen ligand 1, B7-1 antigen), CD80, T-lymphocyte activation antigen CD80, costimulatory factor CD80, B-lymphocyte activation antigen B7, CTLA-4 counter-receptor B7.1
The Cluster of differentiation 80 (also CD80 and B7-1) is a B7, type I membrane protein in the immunoglobulin superfamily, with an extracellular immunoglobulin constant-like domain and a variable-like domain required for receptor binding. It is closely related to CD86, another B7 protein (B7-2), and often works in tandem. Both CD80 and CD86 interact with costimulatory receptors CD28, CTLA-4 (CD152) and the p75 neurotrophin receptor.
Protein · UniProt
T-lymphocyte activation antigen CD80
- Gene
- CD80
- Organism
- Homo sapiens (Human)
- Length
- 288 aa
- Molecular mass
- 33,048 Da
- Evidence
- 1: Evidence at protein level
Costimulatory molecule that belongs to the immunoglobulin superfamily that plays an important role in T-lymphocyte activation (PubMed:38467718). Acts as the primary auxiliary signal augmenting the MHC/TCR signal in naive T-cells by acting as a ligand for the CD28 receptor which is constitutively expressed on the cell surface of T-cells (PubMed:12196291). In turn, activates different signaling pathways such as NF-kappa-B or MAPK leading to the production of different cytokines (PubMed:10438913). Also acts as an inhibitor of T-cell activation by acting as a ligand for CTLA4, a decoy receptor,…
Swiss-Prot (reviewed) · via UniProt
Research
6,170 papers- PD-1 agonism by anti-CD80 inhibits T cell activation and alleviates autoimmunity.Nature immunology · 2022
- Molecular and Functional Analyses of the Primordial Costimulatory Molecule CD80/86 and Its Receptors CD28 and CD152 (CTLA-4) in a Teleost Fish.Frontiers in immunology · 2022
- Research progress of CD80 in the development of immunotherapy drugs.Frontiers in immunology · 2024
- Discovery of selective small-molecule CD80 inhibitors.Journal of biomolecular screening · 2007
- Urinary CD80: a biomarker for a favorable response to corticosteroids in minimal change disease.Pediatric nephrology (Berlin, Germany) · 2018
via PubMed
Clinical Trials
1 registered- PHASE1WITHDRAWNCancer/Testis Antigen Immunotherapy Phase I Study With 740-CTA Vaccinia VirusUniversity Hospital, Basel, Switzerland · NCT03110445
~7 min read
Encyclopedic overview
6 sectionsContents
- Structure
- Function
- Clinical significance
- See also
- References
- External links
The Cluster of differentiation 80 (also CD80 and B7-1) is a B7, type I membrane protein in the immunoglobulin superfamily, with an extracellular immunoglobulin constant-like domain and a variable-like domain required for receptor binding. It is closely related to CD86, another B7 protein (B7-2), and often works in tandem. Both CD80 and CD86 interact with costimulatory receptors CD28, CTLA-4 (CD152) and the p75 neurotrophin receptor.
== Structure == CD80 is a member of the B7 family, which consists of molecules present at APCs and their receptors present on the T-cells. CD80 is present specifically on DC, activated B-cells, and macrophages, but also T-cells. CD80 is also a transmembrane glycoprotein and a member of the Ig superfamily. It is composed of 288 amino acids, and its mass is 33 kDa. It consists of two Ig-like extracellular domains (208 AA), a transmembrane helical segment (21 AA), and a short cytoplasmic tail (25 AA). The Ig-like extracellular domains are formed by single V-type and C2-type domains. It is expressed as both monomers or dimers, but predominantly dimers. These two forms exist in dynamic equilibrium.
Excerpted from Wikipedia’s “CD80 molecule” article, available under the CC BY-SA 4.0 licence.