بروبيردين

Name

complement factor properdin

Type

protein-coding

Chromosome

X

Position

47,621,537–47,630,305 (−)

Aliases

BFD, PFC, PFD, PROPERDIN

Ensembl

ENSG00000126759

RefSeq RNA

NM_001145252.3, NM_002621.2

RefSeq protein

NP_001138724.1, NP_002612.1

This gene encodes a plasma glycoprotein that positively regulates the alternative complement pathway of the innate immune system. This protein binds to many microbial surfaces and apoptotic cells and stabilizes the C3- and C5-convertase enzyme complexes in a feedback loop that ultimately leads to formation of the membrane attack complex and lysis of the target cell. Mutations in this gene result in two forms of properdin deficiency, which results in high susceptibility to meningococcal infections. Multiple alternatively spliced variants, encoding the same protein, have been identified.[provided by RefSeq, Feb 2009].

via MyGene.info

Gene · Ensembl

complement factor properdin

Symbol

CFP

Biotype

Protein coding

Organism

Homo sapiens

Location

Chr X:47,621,537-47,630,305

Strand

Reverse (−)

Assembly

GRCh38

Wikidata facts

Instance of

gene

Has part

carbon

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