Structure via PubChem · Public domain (PubChem)
CGP7930
Sign in to saveAlso known as CGP 7930, CGP-7930
CGP-7930 was the first positive allosteric modulator of GABAB receptors described in literature. CGP7930 is also a GABAA receptor positive allosteric modulator and a blocker of Potassium channels.
Chemical data
- Formula
- C19H32O2
- Molecular weight
- 292.5 g/mol
- IUPAC name
- 2,6-ditert-butyl-4-(3-hydroxy-2,2-dimethylpropyl)phenol
- SMILES
- CC(C)(C)C1=CC(=CC(=C1O)C(C)(C)C)CC(C)(C)CO
- InChIKey
- XLWJPQQFJNGUPA-UHFFFAOYSA-N
- XLogP
- 5.7
- Polar surface area
- 40.5 Ų
- H-bond donors
- 2
- H-bond acceptors
- 2
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Molecule type
- Small molecule
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 292.24023
Show 2 more facts
- chemical formula
- C₁₉H₃₂O₂
- canonical SMILES
- CC(C)(C)C1=CC(=CC(=C1O)C(C)(C)C)CC(C)(C)CO
Sources (1)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- Synthesis
- See also
- References
CGP-7930 was the first positive allosteric modulator of GABAB receptors described in literature. CGP7930 is also a GABAA receptor positive allosteric modulator and a blocker of Potassium channels.
CGP7930 was developed in Novartis and has been used extensively for scientific research. It has anxiolytic effects in animal studies, and has a synergistic effect with GABAB agonists such as baclofen and GHB, as well as reducing self-administration of alcoholic drinks and cocaine.
Excerpted from Wikipedia’s “CGP7930” article, available under the CC BY-SA 4.0 licence.