Structure via PubChem · Public domain (PubChem)
cicletanine
Sign in to saveCicletanine is a furopyridine compound (i.e., has a pyridine ring fused to a furan ring) that is approved in France for the treatment of hypertension. The drug is most commonly known as a diuretic drug, but has a broader range of cardiovascular and metabolic activity characterized extensively in the literature (see "Mechanism" below).
Chemical data
- Formula
- C14H12ClNO2
- Molecular weight
- 261.7 g/mol
- IUPAC name
- 3-(4-chlorophenyl)-6-methyl-1,3-dihydrofuro[3,4-c]pyridin-7-ol
- SMILES
- CC1=NC=C2C(OCC2=C1O)C3=CC=C(C=C3)Cl
- InChIKey
- CVKNDPRBJVBDSS-UHFFFAOYSA-N
- XLogP
- 2.4
- Polar surface area
- 42.4 Ų
- H-bond donors
- 1
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
- Indications
- pulmonary arterial hypertension, cardiovascular disease
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 261.056
Show 3 more facts
- chemical formula
- C₁₄H₁₂ClNO₂
- canonical SMILES
- CC1=NC=C2C(OCC2=C1O)C3=CC=C(C=C3)Cl
- subject has role
- diuretic
Sources (2)
via Wikidata · CC0
~3 min read
Encyclopedic overview
3 sectionsContents
- Mechanism
- References
- External links
Cicletanine is a furopyridine compound (i.e., has a pyridine ring fused to a furan ring) that is approved in France for the treatment of hypertension. The drug is most commonly known as a diuretic drug, but has a broader range of cardiovascular and metabolic activity characterized extensively in the literature (see "Mechanism" below).
Cicletanine was originated and in 1986 launched in France by Paris-based Ipsen, who in 2005 licensed marketing rights in France to Milan-based Recordati for several years (at least until 2010). Ipsen and Recordati both marketed cicletanine under the trade name Tenstaten. The drug is no longer manufactured nor sold by IPSEN; it is currently marketed in France by three generics manufacturers: Viatris, Biogaran, and Teva Pharmaceuticals.
Excerpted from Wikipedia’s “cicletanine” article, available under the CC BY-SA 4.0 licence.