Structure via PubChem · Public domain (PubChem)
cilostazol
Sign in to saveAlso known as OPC-13013, OPC-21, Pletal®, 3,4-dihydro-6-(4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy)-2(1H)-quinolinone, 6-(4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy)-3,4-dihydrocarbostyril, 6-(4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy)-3,4-dihydro-2(1H)-quinolinone, 3,4-dihydro-6-(4-(1-Cyclohexyl-1H-tetrazol-5-yl)butoxy)-2(1H)-quinolinone, 6-(4-(1-Cyclohexyl-1H-tetrazol-5-yl)butoxy)-3,4-dihydrocarbostyril
Cilostazol, sold under the brand name Pletal among others, is a medication used to help the symptoms of intermittent claudication in peripheral vascular disease. It may also be used to prevent stroke. It is taken by mouth.
Chemical data
- Formula
- C20H27N5O2
- Molecular weight
- 369.5 g/mol
- IUPAC name
- 6-[4-(1-cyclohexyltetrazol-5-yl)butoxy]-3,4-dihydro-1H-quinolin-2-one
- SMILES
- C1CCC(CC1)N2C(=NN=N2)CCCCOC3=CC4=C(C=C3)NC(=O)CC4
- InChIKey
- RRGUKTPIGVIEKM-UHFFFAOYSA-N
- XLogP
- 3.1
- Polar surface area
- 81.9 Ų
- H-bond donors
- 1
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Research
2,449 papers- Cilostazol.Drugs & aging · 1999
- Cilostazol.Heart disease (Hagerstown, Md.) · 1999
- Cilostazol for intermittent claudication.The Cochrane database of systematic reviews · 2021
- Repurposing Cilostazol for Raynaud's Phenomenon.Current medicinal chemistry · 2021
- Cilostazol: a Review of Basic Mechanisms and Clinical Uses.Cardiovascular drugs and therapy · 2022
via PubMed
Wikidata facts
- Mass
- 369.216475
Show 5 more facts
- chemical formula
- C₂₀H₂₇N₅O₂
- canonical SMILES
- C1CCC(CC1)N2C(=NN=N2)CCCCOC3=CC4=C(C=C3)NC(=O)CC4
- World Health Organisation international non-proprietary name
- cilostazol
- defined daily dose
- 0.2
- Commons category
- Cilostazol
Sources (8)
via Wikidata · CC0
~3 min read
Article
7 sectionsContents
- Medical uses
- Heart failure
- Adverse effects
- Interactions
- Mechanism
- References
- External links
Cilostazol, sold under the brand name Pletal among others, is a medication used to help the symptoms of intermittent claudication in peripheral vascular disease. It may also be used to prevent stroke. It is taken by mouth.
Common side effects include headache, diarrhea, dizziness, and cough. Serious side effects may include decreased survival in those with heart failure, low platelets, and low white blood cells. Cilostazol is a phosphodiesterase 3 inhibitor which works by inhibiting platelet aggregation and dilating arteries.