cirazoline
Sign in to saveCirazoline is a full agonist at the α1A adrenergic receptor, a partial agonist at both the α1B and α1D adrenergic receptors, and a nonselective antagonist to the α2 adrenergic receptor. It is believed that this combination of properties could make cirazoline an effective vasoconstricting agent.
Research
420 papers- [3H]cirazoline as a tool for the characterization of imidazoline sites.Annals of the New York Academy of Sciences · 1995
- Clonidine and cirazoline inhibit activation of nicotinic channels in PC-12 cells.Annals of the New York Academy of Sciences · 1995
- The alpha-1 adrenergic agonist, cirazoline, impairs spatial working memory performance in aged monkeys.Pharmacology, biochemistry, and behavior · 1997
- Receptor interactions of imidazolines. IX. Cirazoline is an alpha-1 adrenergic agonist and an alpha-2 adrenergic antagonist.The Journal of pharmacology and experimental therapeutics · 1982
- Pharmacologic characterization of cirazoline-activated inositol phospholipid hydrolysis in rat brain cortical slices.Canadian journal of physiology and pharmacology · 1988
via PubMed
Wikidata facts
- Mass
- 216.126263
Show 3 more facts
- chemical formula
- C₁₃H₁₆N₂O
- canonical SMILES
- C1CC1C2=CC=CC=C2OCC3=NCCN3
- Commons category
- Cirazoline
Sources (2)
via Wikidata · CC0
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Article
1 sectionsContents
- References
Cirazoline is a full agonist at the α1A adrenergic receptor, a partial agonist at both the α1B and α1D adrenergic receptors, and a nonselective antagonist to the α2 adrenergic receptor. It is believed that this combination of properties could make cirazoline an effective vasoconstricting agent.
Cirazoline has also been shown to decrease food intake in rats, purportedly through activation of α1 adrenoceptors in the paraventricular nucleus in the hypothalamus of the brain. Administration of cirazoline also seemed to present impairment in the spatial memory of monkeys through the activation of the same receptors that showed decreased food intake in rats. However, in preliminary studies, through stimulation of α2 adrenoceptors, working memory is comparatively improved.