CMA1

Also known as CYH, MCT1, chymase, chymase 1

Chymase is an enzyme that in humans is encoded by the CMA1 gene.

In the Vinony graph

Within Vinony's link graph, CMA1 is referenced by 4 other articles, and connects out to PubMed, human chromosome 14 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 14.

Its subject is documented across 4 Wikipedia language editions.

Gene data

CMA1

Name: chymase 1
Type: protein-coding
Position: 24,505,353–24,508,271 (−)
Aliases: CYH, MCT1, chymase
Ensembl: ENSG00000092009
RefSeq RNA: NM_001308083.2, NM_001836.5
RefSeq protein: NP_001295012.1, NP_001827.1

This gene encodes a chymotryptic serine proteinase that belongs to the peptidase family S1. It is expressed in mast cells and is thought to function in the degradation of the extracellular matrix, the regulation of submucosal gland secretion, and the generation of vasoactive peptides. In the heart and blood vessels, this protein, rather than angiotensin converting enzyme, is largely responsible for converting angiotensin I to the vasoactive peptide angiotensin II. Alternative splicing results in multiple variants. [provided by RefSeq, Apr 2015].

Pathways

Renin-angiotensin system - Homo sapiens (human)Diabetic cardiomyopathy - Homo sapiens (human)Signaling by SCF-KIT Degradation of the extracellular matrix Extracellular matrix organization Activation of Matrix Metalloproteinases Signal Transduction Metabolism of Angiotensinogen to Angiotensins Peptide hormone metabolism Metabolism of proteins

via MyGene.info

Gene · Ensembl

chymase 1

Symbol: CMA1
Biotype: Protein coding
Organism: Homo sapiens
Location: 14:24,505,353-24,508,271
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene
Image: Protein CMA1 PDB 1klt.png

Show 7 more facts

HomoloGene ID: 55606
genomic end: 24977471
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/1215
chromosome: human chromosome 14
genomic start: 24974559
cytogenetic location: 14q12

Sources (4)

via Wikidata · CC0

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Encyclopedic overview

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Contents

References
Further reading
External links

Chymase is an enzyme that in humans is encoded by the CMA1 gene.

This gene product is a chymotryptic serine proteinase that belongs to the peptidase family S1. It is expressed in mast cells and thought to function in the degradation of the extracellular matrix, the regulation of submucosal gland secretion, and the generation of vasoactive peptides. In the heart and blood vessels, this protein, rather than angiotensin converting enzyme, is largely responsible for converting angiotensin I to the vasoactive peptide angiotensin II. Angiotensin II has been implicated in blood pressure control and in the pathogenesis of hypertension, cardiac hypertrophy, and heart failure. Thus, this gene product is a target for cardiovascular disease therapies. This gene maps to 14q11.2 in a cluster of genes encoding other proteases.

Excerpted from Wikipedia’s “CMA1” article, available under the CC BY-SA 4.0 licence.