TFPI

Also known as EPI, LACI, TFI, TFPI1, tissue factor pathway inhibitor

protein-coding gene in the species Homo sapiens

Gene data

TFPI

Name: tissue factor pathway inhibitor
Type: protein-coding
Position: 187,463,823–187,565,846 (−)
Aliases: EPI, LACI, TFI, TFPI1
Ensembl: ENSG00000003436
RefSeq RNA: NM_001032281.4, NM_001318941.3, NM_001329239.2, NM_001329240.2, NM_001329241.2
RefSeq protein: NP_001027452.1, NP_001305870.1, NP_001316168.1, NP_001316169.1, NP_001316170.1

This gene encodes a Kunitz-type serine protease inhibitor that regulates the tissue factor (TF)-dependent pathway of blood coagulation. The coagulation process initiates with the formation of a factor VIIa-TF complex, which proteolytically activates additional proteases (factors IX and X) and ultimately leads to the formation of a fibrin clot. The product of this gene inhibits the activated factor X and VIIa-TF proteases in an autoregulatory loop. Inhibition of the encoded protein restores hemostasis in animal models of hemophilia. This gene encodes multiple protein isoforms that differ in their inhibitory activity, specificity and cellular localization. [provided by RefSeq, Jul 2016].