Coagulation factor XI

Protein · UniProt

Coagulation factor XI

Gene

F11

Organism

Homo sapiens (Human)

Length

625 aa

Molecular mass

70,109 Da

Evidence

1: Evidence at protein level

Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX

• Liver-heart cross-talk mediated by coagulation factor XI protects against heart failure.Science (New York, N.Y.) · 2022
• Factor XI and coagulation. Factor XI inhibitors - antithrombotic perspectives.Romanian journal of internal medicine = Revue roumaine de medecine interne · 2024
• Coagulation factor XI regulates endothelial cell permeability and barrier function in vitro and in vivo.Blood · 2024
• Anticoagulant drugs targeting factor XI/XIa and coagulation tests: we urgently need reliable pharmacodynamic data.Journal of thrombosis and haemostasis : JTH · 2025
• Coagulation factor XI and cardiovascular disease: A complex, cardio-specific conundrum.Med (New York, N.Y.) · 2026

via PubMed

• PHASE3RECRUITING
  REGN7508 Versus Apixaban and Enoxaparin for Thromboprophylaxis After Total Knee Arthroplasty in AdultsRegeneron Pharmaceuticals · NCT07015905
• PHASE3RECRUITING
  Treatment and Secondary Prevention of Venous Thromboembolism (VTE) in Adult Participants With Solid and Hematologic CancersRegeneron Pharmaceuticals · NCT07493304
• PHASE2ACTIVE_NOT_RECRUITING
  Factor XI inhibiTion for the Prevention of Venous Thromboembolism in Patients Undergoing Total Knee ArthroplastySuzhou Alphamab Co., Ltd. · NCT06180889
• NAUNKNOWN
  The Proteins of the Contact Activation SystemHospices Civils de Lyon · NCT02785718
• PHASE2COMPLETED
  A Trial to Learn How Well REGN9933 Works for Preventing Blood Clots After Knee Replacement Surgery in Adult ParticipantsRegeneron Pharmaceuticals · NCT05618808
• UNKNOWN
  Thrombus Formation Under Different Flow-conditionsMaastricht University Medical Center · NCT01114074

via ClinicalTrials.gov

Wikidata facts

Instance of

protein

via Wikidata · CC0