COQ6
Sign in to saveAlso known as CGI10, COQ10D6, CGI-10, coenzyme Q6, monooxygenase
Coenzyme Q6 monooxygenase is a protein that in humans is encoded by the COQ6 gene.
In the Vinony graph
Vinony's link graph records 45 inbound references to COQ6, and connects out to PubMed, human chromosome 14 and Ensembl genome database project.
It is catalogued under the topic Genes on human chromosome 14.
Vinony links it to 5 Wikipedia language editions.
Gene data
COQ6- Name
- coenzyme Q6, monooxygenase
- Type
- protein-coding
- Position
- 73,949,926–73,963,670 (+)
- Aliases
- CGI-10, CGI10, COQ10D6
- Ensembl
- ENSG00000119723
- RefSeq RNA
- NM_001425255.1, NM_001425256.1, NM_001425257.1, NM_001425258.1, NM_001425259.1
- RefSeq protein
- NP_001412184.1, NP_001412185.1, NP_001412186.1, NP_001412187.1, NP_001412188.1
The protein encoded by this gene belongs to the ubiH/COQ6 family. It is an evolutionarily conserved monooxygenase required for the biosynthesis of coenzyme Q10 (or ubiquinone), which is an essential component of the mitochondrial electron transport chain, and one of the most potent lipophilic antioxidants implicated in the protection of cell damage by reactive oxygen species. Knockdown of this gene in mouse and zebrafish results in decreased growth due to increased apoptosis. Mutations in this gene are associated with autosomal recessive coenzyme Q10 deficiency-6 (COQ10D6), which manifests as nephrotic syndrome with sensorineural deafness. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jun 2012].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
coenzyme Q6, monooxygenase
- Symbol
- COQ6
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 14:73,949,926-73,963,670
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 7 more facts
- HomoloGene ID
- 6039
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/51004
- genomic end
- 74430373
- genomic start
- 74416629
- chromosome
- human chromosome 14
- cytogenetic location
- 14q24.3
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
4 sectionsContents
- Function
- Clinical significance
- References
- External links
Coenzyme Q6 monooxygenase is a protein that in humans is encoded by the COQ6 gene.
==Function==
Excerpted from Wikipedia’s “COQ6” article, available under the CC BY-SA 4.0 licence.