CRADD
Sign in to saveAlso known as MRT34, RAIDD, CASP2 and RIPK1 domain containing adaptor with death domain
Death domain-containing protein CRADD is a protein that in humans is encoded by the CRADD gene.
In the Vinony graph
Vinony's link graph records 6 inbound references to CRADD, and connects out to PubMed, human chromosome 12 and Ensembl genome database project.
It is catalogued under the topic Genes on human chromosome 12.
Vinony links it to 6 Wikipedia language editions.
Gene data
CRADD- Name
- CARD and death domain containing adaptor protein
- Type
- protein-coding
- Position
- 93,677,375–93,894,840 (+)
- Aliases
- MRT34, RAIDD
- Ensembl
- ENSG00000169372
- RefSeq RNA
- NM_001320099.2, NM_001320100.2, NM_001320101.3, NM_001330126.1, NM_003805.5
- RefSeq protein
- NP_001307028.1, NP_001307029.1, NP_001307030.1, NP_001317055.1, NP_003796.1
This gene encodes a protein containing a death domain (DD) motif. This protein recruits caspase 2/ICH1 to the cell death signal transduction complex, which includes tumor necrosis factor receptor 1 (TNFR1A) and RIPK1/RIP kinase, and acts in promoting apoptosis. A mutation in this gene was associated with cognitive disability. A related pseudogene is found on chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
CARD and death domain containing adaptor protein
- Symbol
- CRADD
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 12:93,677,375-93,894,840
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein CRADD PDB 2o71.png
Show 7 more facts
- HomoloGene ID
- 2821
- genomic start
- 93677375
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/8738
- genomic end
- 94288616
- chromosome
- human chromosome 12
- cytogenetic location
- 12q22
via Wikidata · CC0
~1 min read
Encyclopedic overview
5 sectionsContents
- Function
- Interactions
- References
- External links
- Further reading
Death domain-containing protein CRADD is a protein that in humans is encoded by the CRADD gene.
== Function ==
Excerpted from Wikipedia’s “CRADD” article, available under the CC BY-SA 4.0 licence.