CRTC2
Sign in to saveAlso known as TORC-2, TORC2, CREB regulated transcription coactivator 2
CREB regulated transcription coactivator 2, also known as CRTC2, is a protein which in humans is encoded by the CRTC2 gene.
Gene data
CRTC2- Name
- CREB regulated transcription coactivator 2
- Type
- protein-coding
- Position
- 153,947,669–153,958,634 (−)
- Aliases
- TORC-2, TORC2
- Ensembl
- ENSG00000160741
- RefSeq RNA
- NM_181715.3, XM_005244946.2, XM_017000575.1, XM_017000576.1, XM_017000577.2
- RefSeq protein
- NP_859066.1, XP_005245003.1, XP_016856064.1, XP_016856065.1, XP_016856066.1
This gene encodes a member of the transducers of regulated cAMP response element-binding protein activity family of transcription coactivators. These proteins promote the transcription of genes targeted by the cAMP response element-binding protein, and therefore play an important role in many cellular processes. Under basal conditions the encoded protein is phosphorylated by AMP-activated protein kinase or the salt-inducible kinases and is sequestered in the cytoplasm. Upon activation by elevated cAMP or calcium, the encoded protein translocates to the nucleus and increases target gene expression. Single nucleotide polymorphisms in this gene may increase the risk of type 2 diabetes. A pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Dec 2010].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Research
523 papersvia PubMed
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 18765
- exact match
- identifiers.org/ncbigene/200186
- genomic start
- 153920145
- genomic end
- 153958615
- cytogenetic location
- 1q21.3
Sources (4)
via Wikidata · CC0
~1 min read
Article
5 sectionsContents
- Function
- Interactions
- References
- Further reading
- External links
CREB regulated transcription coactivator 2, also known as CRTC2, is a protein which in humans is encoded by the CRTC2 gene.
== Function ==