CRTC2

Name

CREB regulated transcription coactivator 2

Type

protein-coding

Position

153,947,669–153,958,642 (−)

Aliases

TORC-2, TORC2

Ensembl

ENSG00000160741

RefSeq RNA

NM_181715.3, XM_005244946.2, XM_017000575.1, XM_017000576.1, XM_017000577.2

RefSeq protein

NP_859066.1, XP_005245003.1, XP_016856064.1, XP_016856065.1, XP_016856066.1

This gene encodes a member of the transducers of regulated cAMP response element-binding protein activity family of transcription coactivators. These proteins promote the transcription of genes targeted by the cAMP response element-binding protein, and therefore play an important role in many cellular processes. Under basal conditions the encoded protein is phosphorylated by AMP-activated protein kinase or the salt-inducible kinases and is sequestered in the cytoplasm. Upon activation by elevated cAMP or calcium, the encoded protein translocates to the nucleus and increases target gene expression. Single nucleotide polymorphisms in this gene may increase the risk of type 2 diabetes. A pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Dec 2010].

via MyGene.info

Gene · Ensembl

CREB regulated transcription coactivator 2

Symbol

CRTC2

Biotype

Protein coding

Organism

Homo sapiens

Location

1:153,947,669-153,958,642

Strand

Reverse (−)

Assembly

GRCh38

via PubMed

Wikidata facts

Instance of

gene

via Wikidata · CC0