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GeneQ18037131· pop 9· linked from 50 articles

CRTC1

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Also known as MECT1, TORC-1, TORC1, WAMTP1, CREB regulated transcription coactivator 1, MAML2, Mam-2

CREB-regulated transcription coactivator 1 (CRTC1), previously referred to as TORC1 (), is a protein that in humans is encoded by the CRTC1 gene. It is expressed in a limited number of tissues that include fetal brain and liver and adult heart, skeletal muscles, liver and salivary glands and various regions of the adult central nervous system.

Gene data

CRTC1
Name
CREB regulated transcription coactivator 1
Type
protein-coding
Position
18,683,575–18,782,333 (+)
Aliases
MAML2, MECT1, Mam-2, TORC-1, TORC1, WAMTP1
Ensembl
ENSG00000105662
RefSeq RNA
NM_001098482.2, NM_015321.3, NM_025021.1
RefSeq protein
NP_001091952.1, NP_056136.2

Enables cAMP response element binding protein binding activity. Involved in positive regulation of transcription by RNA polymerase II. Located in cytosol; nuclear body; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

Gene Ontology

Pathways

Human T-cell leukemia virus 1 infection - Homo sapiens (human)Mitochondrial biogenesisOrganelle biogenesis and maintenanceTranscriptional activation of mitochondrial biogenesisCellular responses to stressCellular responses to stimuliHeme signalingCircadian clockExpression of BMAL (ARNTL), CLOCK, and NPAS2Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes

via MyGene.info

Gene · Ensembl

CREB regulated transcription coactivator 1

Symbol
CRTC1
Biotype
Protein coding
Organism
Homo sapiens
Location
19:18,683,575-18,782,333
Strand
Forward (+)
Assembly
GRCh38
View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of
gene
Show 9 more facts
HomoloGene ID
41607
found in taxon
Homo sapiens
genetic association
Barrett's esophagus
exact match
identifiers.org/ncbigene/23373
genomic start
18683678
cytogenetic location
19p13.11
chromosome
human chromosome 19
genomic end
18893004
expressed in
cingulate gyrus
Sources (6)

via Wikidata · CC0

~1 min read

Encyclopedic overview

5 sections
Contents
  • Clinical significance
  • See also
  • References
  • Further reading
  • External links

CREB-regulated transcription coactivator 1 (CRTC1), previously referred to as TORC1 (), is a protein that in humans is encoded by the CRTC1 gene. It is expressed in a limited number of tissues that include fetal brain and liver and adult heart, skeletal muscles, liver and salivary glands and various regions of the adult central nervous system.

== Clinical significance ==

Excerpted from Wikipedia’s “CRTC1” article, available under the CC BY-SA 4.0 licence.

Available in 8 languages

via Wikidata sitelinks · CC0