NCOA2

Name

nuclear receptor coactivator 2

Type

protein-coding

Position

70,109,772–70,456,452 (−)

Aliases

GRIP1, KAT13C, NCoA-2, SRC-2, SRC2, TIF2, bHLHe75

Ensembl

ENSG00000140396

RefSeq RNA

NM_001321703.2, NM_001321707.2, NM_001321711.2, NM_001321712.2, NM_001321713.2

RefSeq protein

NP_001308632.1, NP_001308636.1, NP_001308640.1, NP_001308641.1, NP_001308642.1

The protein encoded by this gene functions as a transcriptional coactivator for nuclear hormone receptors, including steroid, thyroid, retinoid, and vitamin D receptors. The encoded protein acts as an intermediary factor for the ligand-dependent activity of these nuclear receptors, which regulate their target genes upon binding of cognate response elements. This gene has been found to be involved in translocations that result in fusions with other genes in various cancers, including the lysine acetyltransferase 6A (KAT6A) gene in acute myeloid leukemia, the ETS variant 6 (ETV6) gene in acute lymphoblastic leukemia, and the hes related family bHLH transcription factor with YRPW motif 1 (HEY1) gene in mesenchymal chondrosarcoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016].

via MyGene.info

Gene · Ensembl

nuclear receptor coactivator 2

Symbol

NCOA2

Biotype

Protein coding

Organism

Homo sapiens

Location

8:70,109,772-70,456,452

Strand

Reverse (−)

Assembly

GRCh38