DDR2

Name

discoidin domain receptor tyrosine kinase 2

Type

protein-coding

Position

162,630,863–162,787,405 (+)

Aliases

DDR2-N, MIG20a, NTRKR3, TKT, TYRO10, WRCN

Ensembl

ENSG00000162733

RefSeq RNA

NM_001014796.3, NM_001354982.2, NM_001354983.2, NM_006182.4, XM_011509587.3

RefSeq protein

NP_001014796.1, NP_001341911.1, NP_001341912.1, NP_006173.2, XP_011507889.1

This gene encodes a member of the discoidin domain receptor subclass of the receptor tyrosine kinase (RTKs) protein family. RTKs play a key role in the communication of cells with their microenvironment. The encoded protein is a collagen-induced receptor that activates signal transduction pathways involved in cell adhesion, proliferation, and extracellular matrix remodeling. This protein is expressed in numerous cell types and may alos be involved in wound repair and regulate tumor growth and invasiveness. Mutations in this gene are the cause of short limb-hand type spondylometaepiphyseal dysplasia. [provided by RefSeq, Aug 2017].

via MyGene.info

Wikidata facts

Image

Protein DDR2 PDB 2WUH.png

via Wikidata · CC0