CTBP1
Sign in to saveAlso known as C-terminal binding protein 1, BARS, HADDTS
C-terminal-binding protein 1 also known as CtBP1 is a protein that in humans is encoded by the CTBP1 gene. CtBP1 is one of two CtBP proteins, the other protein being CtBP2.
Gene data
CTBP1- Name
- C-terminal binding protein 1
- Type
- protein-coding
- Position
- 1,211,434–1,250,333 (−)
- Aliases
- BARS, HADDTS
- Ensembl
- ENSG00000159692
- RefSeq RNA
- NM_001012614.2, NM_001328.3, NM_001377186.1, NM_001377187.1, NM_001377188.1
- RefSeq protein
- NP_001012632.1, NP_001319.1, NP_001364115.1, NP_001364116.1, NP_001364117.1
This gene encodes a protein that binds to the C-terminus of adenovirus E1A proteins. This phosphoprotein is a transcriptional repressor and may play a role during cellular proliferation. This protein and the product of a second closely related gene, CTBP2, can dimerize. Both proteins can also interact with a polycomb group protein complex which participates in regulation of gene expression during development. Alternative splicing of transcripts from this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Wikidata facts
- Image
- 6cdf.jpg
Show 5 more facts
- HomoloGene ID
- 1015
- exact match
- identifiers.org/ncbigene/1487
- genomic end
- 1243741
- genomic start
- 1211445
- cytogenetic location
- 4p16.3
Sources (4)
via Wikidata · CC0
~3 min read
Article
5 sectionsContents
- Function
- Interactions
- References
- Further reading
- External links
C-terminal-binding protein 1 also known as CtBP1 is a protein that in humans is encoded by the CTBP1 gene. CtBP1 is one of two CtBP proteins, the other protein being CtBP2.
==Function== The CtBP1 protein was originally identified as a human protein that bound a PLDLS motif in the C-terminus of adenovirus E1A proteins. It and the related protein CTBP2 were later shown to function as transcriptional corepressors. That is, regulatory proteins that bind to sequence-specific DNA-binding proteins and help turn genes off. CtBPs do this by recruiting histone modifying enzymes that add repressive histone marks and remove activating marks. CtBP proteins can also self-associate and presumably bring together gene regulatory complexes.