Forkhead box P2
Sign in to saveAlso known as trinucleotide repeat-containing gene 10 protein, CAG repeat protein 44, forkhead/winged-helix transcription factor, trinucleotide repeat containing 10, forkhead box protein P2, FOXP2
Forkhead box protein P2 (FOXP2) is a protein that, in humans, is encoded by the FOXP2 gene. FOXP2 is a member of the forkhead box family of transcription factors, proteins that regulate gene expression by binding to DNA. It is expressed in the brain, heart, lungs and digestive system.
Protein · UniProt
Forkhead box protein P2
- Gene
- FOXP2
- Organism
- Homo sapiens (Human)
- Length
- 715 aa
- Molecular mass
- 79,919 Da
- Evidence
- 1: Evidence at protein level
Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Plays a role in synapse formation by regulating SRPX2 levels. Involved in neural mechanisms mediating the development of speech and language
Swiss-Prot (reviewed) · via UniProt
Wikidata facts
- Image
- FOXP2 (2as5).png
Show 2 more facts
- Commons category
- FOXP2
- exact match
- purl.uniprot.org/uniprot/O15409
via Wikidata · CC0
~21 min read
Article
15 sectionsContents
- Structure and function
- Clinical significance
- Language disorder
- Evolution
- Interactions
- In other animals
- <span id="Chimpanzees compared with humans"></span>Chimpanzees
- Mice
- Bats
- Birds
- Zebrafish
- History
- See also
- References
- External links
Forkhead box protein P2 (FOXP2) is a protein that, in humans, is encoded by the FOXP2 gene. FOXP2 is a member of the forkhead box family of transcription factors, proteins that regulate gene expression by binding to DNA. It is expressed in the brain, heart, lungs and digestive system.
FOXP2 is found in many vertebrates, where it plays an important role in mimicry in birds (such as birdsong) and echolocation in bats. FOXP2 is also required for the proper development of speech and language in humans. In humans, mutations in FOXP2 cause the severe speech and language disorder developmental verbal dyspraxia. Studies of the gene in mice and songbirds indicate that it is necessary for vocal imitation and the related motor learning. Outside the brain, FOXP2 has also been implicated in development of other tissues such as the lung and digestive system.