CYP2C8

Also known as CPC8, CYPIIC8, MP-12/MP-20, cytochrome P450 family 2 subfamily C member 8, CYP2C8DM

Cytochrome P4502C8 (CYP2C8) is a member of the cytochrome P450 mixed-function oxidase system involved in the metabolism of xenobiotics in the body. Cytochrome P4502C8 also possesses epoxygenase activity, i.e. it metabolizes long-chain polyunsaturated fatty acids, e.g. arachidonic acid, eicosapentaenoic acid, docosahexaenoic acid, and linoleic acid to their biologically active epoxides.

Gene data

CYP2C8

Name: cytochrome P450 family 2 subfamily C member 8
Type: protein-coding
Position: 95,034,359–95,069,498 (−)
Aliases: CPC8, CYP2C8DM, CYPIIC8, MP-12/MP-20
Ensembl: ENSG00000138115
RefSeq RNA: NM_000770.3, NM_001198853.1, NM_001198854.1, NM_001198855.1, NM_030878.1
RefSeq protein: NP_000761.3, NP_001185782.1, NP_001185783.1, NP_001185784.1

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, benzo(a)pyrene, 7-ethyoxycoumarin, and the anti-cancer drug taxol. This gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Nov 2010].