Structure via PubChem · Public domain (PubChem)
zonisamide
Also known as AD-810, CI-912, PD-110843, Zonegran®, 1,2-Benzisoxazole-3-methanesulfonamide, 3-(Sulfamoylmethyl)-1,2-benzisoxazole, Zonisamida
Zonisamide, sold under the brand name Zonegran among others, is a medication used to treat the symptoms of epilepsy and Parkinson's disease. Chemically it is a sulfonamide. It serves as an anticonvulsant used primarily as an adjunctive therapy in adults with Parkinson's disease, partial-onset seizures; infantile spasm, mixed seizure types of Lennox–Gastaut syndrome, myoclonic and generalized tonic clonic seizure. Despite this it is also sometimes used as a monotherapy for partial-onset seizures.
Chemical data
- Formula
- C8H8N2O3S
- Molecular weight
- 212.23 g/mol
- IUPAC name
- 1,2-benzoxazol-3-ylmethanesulfonamide
- SMILES
- C1=CC=C2C(=C1)C(=NO2)CS(=O)(=O)N
- InChIKey
- UBQNRHZMVUUOMG-UHFFFAOYSA-N
- XLogP
- 0.2
- Polar surface area
- 94.6 Ų
- H-bond donors
- 1
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Research
1,787 papers~5 min read
Article
16 sectionsContents
- Medical uses
- Epilepsy
- Parkinson's disease
- Adverse effects
- Interactions
- Mechanism of action
- Pharmacokinetics
- Absorption
- Metabolism
- History
- Research
- Tardive dyskinesia
- Obesity
- Migraine
- Bipolar depression
- References
Zonisamide, sold under the brand name Zonegran among others, is a medication used to treat the symptoms of epilepsy and Parkinson's disease. Chemically it is a sulfonamide. It serves as an anticonvulsant used primarily as an adjunctive therapy in adults with Parkinson's disease, partial-onset seizures; infantile spasm, mixed seizure types of Lennox–Gastaut syndrome, myoclonic and generalized tonic clonic seizure. Despite this it is also sometimes used as a monotherapy for partial-onset seizures.
In 2020, it was the 276th most commonly prescribed medication in the United States, with more than 1million prescriptions.