داكتينومايسين

Key facts

Drug.Verifiedfields

changed

Drug.Watchedfields

changed

Drug.verifiedrevid

477241639

Drug.IUPAC_name

2-Amino-N,''- bis[(6S,9R,10S,13R,18aS)-6,13-diisopropyl-2,5,9-trimethyl-1,4,7,11,14-pentaoxohexadecahydro-1H-pyrrolo[2,1-i][1,4,7,10,13]oxatetraazacyclohexadecin-10-yl]-4,6-dimethyl-3-oxo-3H''-phenoxazine-1,9-dicarboxamide

Drug.image

Actinomycin C1.svg

Drug.image_class

skin-invert-image

Drug.image2

Actinomycin D sticks.png

Drug.image_class2

bg-transparent

Drug.tradename

Cosmegen

Drug.MedlinePlus

a682224

Drug.pregnancy_AU

D

Drug.pregnancy_US

D

Drug.legal_AU

S4

Drug.legal_CA

Rx-only

Drug.legal_UK

POM

Drug.legal_US

Rx-only

Drug.routes_of_administration

IV

Drug.protein_bound

5%

via Wikipedia infobox

Chemical data

Formula

C62H86N12O16

Molecular weight

1255.4 g/mol

IUPAC name

2-amino-4,6-dimethyl-3-oxo-1-N,9-N-bis[(3R,6S,7R,10S,16S)-7,11,14-trimethyl-2,5,9,12,15-pentaoxo-3,10-di(propan-2-yl)-8-oxa-1,4,11,14-tetrazabicyclo[14.3.0]nonadecan-6-yl]phenoxazine-1,9-dicarboxamide

SMILES

C[C@@H]1[C@@H](C(=O)N[C@@H](C(=O)N2CCC[C@H]2C(=O)N(CC(=O)N([C@H](C(=O)O1)C(C)C)C)C)C(C)C)NC(=O)C3=C4C(=C(C=C3)C)OC5=C(C(=O)C(=C(C5=N4)C(=O)N[C@H]6[C@H](OC(=O)[C@@H](N(C(=O)CN(C(=O)[C@@H]7CCCN7C(=O)[C@H](NC6=O)C(C)C)C)C)C(C)C)C)N)C

InChIKey

RJURFGZVJUQBHK-IIXSONLDSA-N

XLogP

3.8

Polar surface area

356 Ų

H-bond donors

5

H-bond acceptors

18

Formal charge

0

via PubChem

Drug data · ChEMBL

Max clinical phase

Approved

Molecule type

Protein

First approval

1964

Admin. routes

parenteral

Indications

Ewing sarcoma, alveolar rhabdomyosarcoma, embryonal rhabdomyosarcoma, leukemia

via ChEMBL · EBI

• Dactinomycin potentiation of radiation pneumonitis: a forgotten interaction.Pediatric hematology and oncology · 1991
• Dactinomycin in acute myeloid leukemia with NPM1 mutations.European journal of haematology · 2020
• Dactinomycin.The Medical letter on drugs and therapeutics · 1965
• Correction: Dactinomycin dose.Annals of internal medicine · 1983
• [Importance of dactinomycin in the current therapy of tumors].Antibiotiki i meditsinskaia biotekhnologiia = Antibiotics and medical biotechnology · 1985

via PubMed

Wikidata facts

Has part

nitrogen

Mass

1254.628

Has use

medication

via Wikidata · CC0