pegaspargase

Also known as L-asparagine amidohydrolase, putative L-asparaginase precursor

Pegaspargase, sold under the brand name Oncaspar, is a medication used in the treatment of acute lymphoblastic leukemia (ALL). Often it is used together with anthracycline, vincristine, and corticosteroids (for example prednisone and dexamethasone). Pegaspargase can be administered either via an intravenous infusion or a intramuscular injection.

Key facts

Drug.Verifiedfields: changed
Drug.verifiedrevid: 458268975
Drug.image: Pegaspargasa.png
Drug.tradename: Oncaspar
Drug.MedlinePlus: a695031
Drug.DailyMedID: Pegaspargase
Drug.pregnancy_AU: D
Drug.routes_of_administration: Intramuscular, intravenous
Drug.ATC_prefix: L01
Drug.ATC_suffix: XX24
Drug.legal_AU: S4
Drug.legal_CA: Rx-only
Drug.legal_US: Rx-only
Drug.legal_EU: Rx-only
Drug.CAS_number: 130167-69-0
Drug.DrugBank: DB00059
Drug.ChemSpiderID: none
Drug.UNII: 7D96IR0PPM

via Wikipedia infobox

Research

547 papers

Pegaspargase.2006
Pegaspargase in Practice: Minimizing Toxicity, Maximizing Benefit.Current hematologic malignancy reports · 2021
Pegaspargase: A Review in Acute Lymphoblastic Leukaemia.Drugs · 2019
Pegaspargase-induced hypertriglyceridemia in a patient with acute lymphoblastic leukemia.Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners · 2020
Pegaspargase-modified risk-oriented program for adult acute lymphoblastic leukemia: results of the GIMEMA LAL1913 trial.Blood advances · 2023

via PubMed

Wikidata facts

Show 1 more fact

World Health Organisation international non-proprietary name: pegaspargase

Sources (2)

via Wikidata · CC0

~1 min read

Article

1 sections

Contents

References

Known side effects include allergic reactions, coagulopathy, high blood sugar, affecting liver function, pancreas inflammation, and blood clots in the brain. There is no data regarding the usage of pegaspargase during pregnancy. Therefore, caution should be observed and pegaspargase should only be used during pregnancy when the benefits outweigh the possible risks.