DADLE
Sign in to saveAlso known as [D-Ala2, D-Leu5]-enkephalin, DADL, leucine enkephalin-2-alanine, 2-D-alanine-5-D-leucine-enkephalin
DADLE ([D-Ala2, D-Leu5]-Enkephalin) is a synthetic opioid peptide with analgesic properties. Although it is often considered a selective δ-opioid receptor agonist, it also binds to the μ1 subtype of μ-opioid receptors.
Research
1,800 papers- DADLE promotes motor function recovery by inhibiting cytosolic phospholipase A(2) mediated lysosomal membrane permeabilization after spinal cord injury.British journal of pharmacology · 2024
- [D-Ala2, D-Leu5]-enkephalin (DADLE) provides protection against myocardial ischemia reperfusion injury by inhibiting Wnt/β-Catenin pathway.BMC cardiovascular disorders · 2024
- Multifaceted Effects of Delta Opioid Receptors and DADLE in Diseases of the Nervous System.Current drug discovery technologies · 2018
- DADLE improves hepatic ischemia/reperfusion injury in mice via activation of the Nrf2/HO‑1 pathway.Molecular medicine reports · 2017
- DADLE induces a reversible hibernation-like state in HeLa cells.Histochemistry and cell biology · 2006
via PubMed
Wikidata facts
- Mass
- 569.284949
Show 3 more facts
- chemical formula
- C₂₉H₃₉N₅O₇
- canonical SMILES
- CC(C)CC(C(=O)O)NC(=O)C(CC1=CC=CC=C1)NC(=O)CNC(=O)C(C)NC(=O)C(CC2=CC=C(C=C2)O)N
- isomeric SMILES
- C[C@H](C(=O)NCC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@H](CC(C)C)C(=O)O)NC(=O)[C@H](CC2=CC=C(C=C2)O)N
Sources (2)
via Wikidata · CC0
~1 min read
Article
2 sectionsContents
- See also
- References
DADLE ([D-Ala2, D-Leu5]-Enkephalin) is a synthetic opioid peptide with analgesic properties. Although it is often considered a selective δ-opioid receptor agonist, it also binds to the μ1 subtype of μ-opioid receptors.
Treatment with DADLE results in transient depression of mean arterial blood pressure and heart rate.
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