Structure via PubChem · Public domain (PubChem)
دالستراپیب
Sign in to saveAlso known as Dalcetrapib
Dalcetrapib (INN, development code JTT-705) is a CETP inhibitor which was originally being developed by F. Hoffmann–La Roche until May 2012. DalCor Pharmaceuticals licensed dalcetrapib as a potential pioneering precision medicine for patients with cardiovascular disease. By combining genetic and clinical insights into the development program, dalcetrapib is intended to reduce fatal and non-fatal myocardial infarction (MI) following a recent acute coronary syndrome (ACS) and deliver superior cardiovascular outcome in a specific genetic subset of patients. A companion diagnostic test, developed
Chemical data
- Formula
- C23H35NO2S
- Molecular weight
- 389.6 g/mol
- IUPAC name
- S-[2-[[1-(2-ethylbutyl)cyclohexanecarbonyl]amino]phenyl] 2-methylpropanethioate
- SMILES
- CCC(CC)CC1(CCCCC1)C(=O)NC2=CC=CC=C2SC(=O)C(C)C
- InChIKey
- YZQLWPMZQVHJED-UHFFFAOYSA-N
- XLogP
- 7.1
- Polar surface area
- 71.5 Ų
- H-bond donors
- 1
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 3
- Molecule type
- Small molecule
- Indications
- cardiovascular disease, coronary artery disease, acute coronary syndrome, peripheral arterial disease
via ChEMBL · EBI
Research
266 papers- Clinical Pharmacokinetics and Pharmacodynamics of Dalcetrapib.Clinical pharmacokinetics · 2018
- Pharmacogenetics-guided dalcetrapib therapy after an acute coronary syndrome.European heart journal · 2022
- Dalcetrapib: a review of Phase II data.Expert opinion on investigational drugs · 2010
- Dalcetrapib and anacetrapib increase apolipoprotein E-containing HDL in rabbits and humans.Journal of lipid research · 2023
- Effects of dalcetrapib in patients with a recent acute coronary syndrome.The New England journal of medicine · 2012
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 389.239
Show 3 more facts
- chemical formula
- C₂₃H₃₅NO₂S
- canonical SMILES
- CCC(CC)CC1(CCCCC1)C(=O)NC2=CC=CC=C2SC(=O)C(C)C
- Commons category
- Dalcetrapib
Sources (2)
via Wikidata · CC0