(-)-demecolcine
Sign in to saveAlso known as Colcemid, Santavy's substance F, N-desacetyl-N-methylcolchicine, N-methyl-N-desacetylcolchicine, N-deacetyl-N-methylcolchicine, (-)-colchamine, N-methyl-N-deacetylcolchicine, Reichstein's F
Demecolcine (INN; also known as colcemid) is a drug used in chemotherapy. It is closely related to the natural alkaloid colchicine with the replacement of the acetyl group on the amino moiety with methyl, but it is less toxic. It depolymerises microtubules and limits microtubule formation (inactivates spindle fibre formation), thus arresting cells in metaphase and allowing cell harvest and karyotyping to be performed.
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Encyclopedic overview
3 sectionsContents
- Mechanism of action
- Research use
- References
Demecolcine (INN; also known as colcemid) is a drug used in chemotherapy. It is closely related to the natural alkaloid colchicine with the replacement of the acetyl group on the amino moiety with methyl, but it is less toxic. It depolymerises microtubules and limits microtubule formation (inactivates spindle fibre formation), thus arresting cells in metaphase and allowing cell harvest and karyotyping to be performed.
During cell division, demecolcine inhibits mitosis at metaphase by inhibiting spindle formation. Medically, demecolcine has been used to improve the results of cancer radiotherapy by synchronising tumour cells at metaphase, the radiosensitive stage of the cell cycle.
Excerpted from Wikipedia’s “(-)-demecolcine” article, available under the CC BY-SA 4.0 licence.
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