dicyclohexylcarbodiimide
Also known as bis(cyclohexyl)carbodiimide, N,N'-dicyclohexylcarbodiimide, 1,3-dicyclohexylcarbodiimide, DCC, carbodicyclohexylimide, N,N'-methanediylidenedicyclohexanamine, DCCD, DCCI
is an organic compound with the chemical formula (C6H11N)2C. It is a waxy white solid with a sweet odor. Its primary use is to couple amino acids during artificial peptide synthesis. The low melting point of this material allows it to be melted for easy handling. It is highly soluble in dichloromethane, tetrahydrofuran, acetonitrile and dimethylformamide, but insoluble in water.
Research
2,685 papers- Reaction of dicyclohexylcarbodiimide with mitochondrial proteins.Biochimica et biophysica acta · 1993
- Dicyclohexylcarbodiimide interaction with the voltage-dependent anion channel from sarcoplasmic reticulum.European journal of biochemistry · 1998
- Dicyclohexylcarbodiimide commonly causes contact dermatitis but can also be acutely tissue cytotoxic.Contact dermatitis · 2022
- Outbreak of contact allergy to dicyclohexylcarbodiimide in a biotechnology laboratory.Contact dermatitis · 2025
- The effect of N,N'-dicyclohexylcarbodiimide on enzymes of bioenergetic relevance.Biochimica et biophysica acta · 1984
via PubMed
Article
12 sectionsContents
- Structure and spectroscopy
- Preparation
- Other methods
- Reactions
- Amide, peptide, and ester formation
- Moffatt oxidation
- Other reactions
- Biological action
- Safety
- See also
- References
- External links
is an organic compound with the chemical formula (C6H11N)2C. It is a waxy white solid with a sweet odor. Its primary use is to couple amino acids during artificial peptide synthesis. The low melting point of this material allows it to be melted for easy handling. It is highly soluble in dichloromethane, tetrahydrofuran, acetonitrile and dimethylformamide, but insoluble in water.
==Structure and spectroscopy== The C−N=C=N−C core of carbodiimides (N=C=N) is linear, being related to the structure of allene. The molecule has idealized C2 symmetry.