Structure via PubChem · Public domain (PubChem)
dicyclomine
Sign in to saveAlso known as Bentyl®, Byclomine®, Dicycloverin, Dicycloverinum, Dicycloverine, Bicyclohexyl-1-carboxylic acid 2-diethylamino-ethyl ester, 2-(Diethylamino)ethyl 1-cyclohexylcyclohexanecarboxylate
Dicycloverine, also known as dicyclomine, sold under the brand name Bentyl among others, is a medication that is used to treat spasms of the intestines such as those that occur in irritable bowel syndrome (IBS). It is taken by mouth or by injection into a muscle. While it has been used in baby colic and enterocolitis, evidence does not support these uses.
Key facts
- Drug.Watchedfields
- changed
- Drug.class
- Antimuscarinic
- Drug.verifiedrevid
- 460784129
- Drug.image
- Dicyclomine.svg
- Drug.image_class
- skin-invert-image
- Drug.tradename
- Byclomine, Bentyl, Dibent, others
- Drug.MedlinePlus
- a684007
- Drug.DailyMedID
- Dicyclomine
- Drug.pregnancy_AU
- B1
- Drug.ATC_prefix
- A03
- Drug.ATC_suffix
- AA07
- Drug.legal_AU
- S4
- Drug.legal_CA
- Rx-only
- Drug.legal_UK
- POM
- Drug.legal_US
- Rx-only
- Drug.routes_of_administration
- By mouth, intramuscular
- Drug.protein_bound
- >99%
- Drug.elimination_half life
- 5 hours
via Wikipedia infobox
Chemical data
- Formula
- C19H35NO2
- Molecular weight
- 309.5 g/mol
- IUPAC name
- 2-(diethylamino)ethyl 1-cyclohexylcyclohexane-1-carboxylate
- SMILES
- CCN(CC)CCOC(=O)C1(CCCCC1)C2CCCCC2
- InChIKey
- CURUTKGFNZGFSE-UHFFFAOYSA-N
- XLogP
- 5.5
- Polar surface area
- 29.5 Ų
- H-bond donors
- 0
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Research
559 papers- Dicyclomine.2006
- Dicyclomine.2012
- Problematic dicyclomine use: A case report and narrative review.Asian journal of psychiatry · 2020
- Nausea and vomiting of pregnancy and hyperemesis gravidarum.Nature reviews. Disease primers · 2019
- Investigation of anti-Parkinson activity of dicyclomine.The International journal of neuroscience · 2022
via PubMed
~5 min read
Encyclopedic overview
11 sectionsContents
- Medical uses
- Irritable bowel syndrome
- Anxiety
- Contraindications
- Adverse effects
- Pharmacology
- Pharmacodynamics
- History
- Society and culture
- References
- External links
Dicycloverine, also known as dicyclomine, sold under the brand name Bentyl among others, is a medication that is used to treat spasms of the intestines such as those that occur in irritable bowel syndrome (IBS). It is taken by mouth or by injection into a muscle. While it has been used in baby colic and enterocolitis, evidence does not support these uses.
Common side effects include dry mouth, blurred vision, weakness, sleepiness, and lightheadedness. Serious side effects may include psychosis and breathing problems in babies. Use in pregnancy appears to be safe while use during breastfeeding is not recommended. How it works is not entirely clear.
Excerpted from Wikipedia’s “dicyclomine” article, available under the CC BY-SA 4.0 licence.