diritromicina

Also known as Dynabac, Nortron, LY-237216

Antibiotico macrolidico glicopeptidico

In the Vinony graph

Vinony's link graph records 113 inbound references to diritromicina, and connects out to neomycin, antibiotic and digital object identifier.

It is catalogued under topics including Drugboxes which contain changes to verified fields, Drugs with no legal status and ECHA InfoCard ID from Wikidata.

Vinony links it to 13 Wikipedia language editions.

Key facts

Drug.Verifiedfields: changed
Drug.verifiedrevid: 460794200
Drug.IUPAC_name: (2R,3R,6R,7S,8S,9R,10R,12R,13S,15R,17S)-9-{[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy}-3-ethyl-2,10-dihydroxy-7-{[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy}-15-[(2-methoxyethoxy)methyl]-2,6,8,10,12,17-hexamethyl-4,16-dioxa-14-azabicyclo[11.3.1]heptadecan-5-one
Drug.image: Dirithromycin.svg
Drug.image_class: skin-invert-image
Drug.width: 280
Drug.tradename: Dynabac
Drug.MedlinePlus: a604026
Drug.licence_US: Clarithromycin
Drug.pregnancy_category: B
Drug.routes_of_administration: Oral
Drug.bioavailability: 10%
Drug.protein_bound: 15 to 30%
Drug.metabolism: Hyrolized to erythromycyclamine in 1.5 hours
Drug.CAS_number: 62013-04-1
Drug.ATC_prefix: J01
Drug.ATC_suffix: FA13
Drug.PubChem: 6917067

via Wikipedia infobox

Chemical data

Formula: C42H78N2O14
Molecular weight: 835.1 g/mol
IUPAC name: (1R,2R,3R,6R,7S,8S,9R,10R,12R,13S,15R,17S)-9-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-3-ethyl-2,10-dihydroxy-7-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-15-(2-methoxyethoxymethyl)-2,6,8,10,12,17-hexamethyl-4,16-dioxa-14-azabicyclo[11.3.1]heptadecan-5-one
SMILES: CC[C@@H]1[C@@]([C@H]2[C@H]([C@H]([C@@H](C[C@@]([C@@H]([C@H]([C@@H]([C@H](C(=O)O1)C)O[C@H]3C[C@@]([C@H]([C@@H](O3)C)O)(C)OC)C)O[C@H]4[C@@H]([C@H](C[C@H](O4)C)N(C)C)O)(C)O)C)N[C@H](O2)COCCOC)C)(C)O
InChIKey: WLOHNSSYAXHWNR-DWIOZXRMSA-N
XLogP: 4.2
Polar surface area: 196 Å²
H-bond donors: 5
H-bond acceptors: 16
Formal charge: 0

via PubChem

Research

166 papers

Dirithromycin: a new macrolide.The Annals of pharmacotherapy · 1996
Pharmacokinetics of dirithromycin.The Journal of antimicrobial chemotherapy · 1993
Dirithromycin. A review of its antimicrobial activity, pharmacokinetic properties and therapeutic efficacy.Drugs · 1994
Drug interactions of macrolides: emphasis on dirithromycin.The Annals of pharmacotherapy · 1997
Five-day dirithromycin therapy is as effective as seven-day erythromycin therapy for acute exacerbations of chronic bronchitis.The Journal of antimicrobial chemotherapy · 1999

via PubMed

Wikidata facts

Subclass of: chemical compound
Mass: 834.545305176
Has use: medication

Show 6 more facts

chemical formula: C₄₂H₇₈N₂O₁₄
medical condition treated: staphylococcal infection
defined daily dose: 0.5
subject has role: antibiotic
isomeric SMILES: CC[C@@H]1[C@@]([C@H]2[C@H]([C@H]([C@@H](C[C@@]([C@@H]([C@H]([C@@H]([C@H](C(=O)O1)C)O[C@H]3C[C@@]([C@H]([C@@H](O3)C)O)(C)OC)C)O[C@H]4[C@@H]([C@H](C[C@H](O4)C)N(C)C)O)(C)O)C)N[C@H](O2)COCCOC)C)(C)O
canonical SMILES: CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(O)C(C)O2)C(C)C(OC2OC(C)CC(N(C)C)C2O)C(C)(O)CC(C)C2NC(COCCOC)OC(C2C)C1(C)O

Sources (3)

via Wikidata · CC0

Article · Italiano

La diritromicina è un antibiotico macrolidico glicopeptidico.È utilizzata per il trattamento di infezioni lievi o moderate causate da ceppi sensibili di microrganismi, in particolare nei casi di bronchite cronica, polmonite, faringite, tonsillite e di infezioni della pelle senza complicanze.

Abstract from DBpedia / Wikipedia · CC BY-SA