flurithromycin

Also known as antibiotic P 80206, P-0501A, P 80206, Cl-932, 8-fluoroerythromycin, (8S)-8-fluoroerythromycin A

Flurithromycin is a second generation macrolide antibiotic. It is a fluorinated derivative of erythromycin A. It is a broad spectrum antibiotic with similar bactericidal action to erythromycin. Unlike erythromycin, flurithromycin is more tolerant of acidic environments, meaning more survives the digestion process, resulting in higher serum levels, and more efficacious elimination of susceptible bacteria, including staphylococcus aureus and streptococcus pyogenes.

Research

47 papers

Flurithromycin-induced acute interstitial nephritis.The Pediatric infectious disease journal · 2000
Flurithromycin ethylsuccinate in the treatment of lower respiratory tract bacterial infections.Infection · 1994
Antibacterial profile of flurithromycin, a new macrolide.The Journal of antimicrobial chemotherapy · 1992
Analysis of macrolide antibiotics.Journal of chromatography. A · 1998
Levels of flurithromycin in female genital tissue.Antimicrobial agents and chemotherapy · 1995

via PubMed

Wikidata facts

Mass: 751.452

Show 4 more facts

chemical formula: C₃₇H₆₆FNO₁₃
canonical SMILES: CCC1C(C(C(C(=O)C(CC(C(C(C(C(C(=O)O1)C)OC2CC(C(C(O2)C)O)(C)OC)C)OC3C(C(CC(O3)C)N(C)C)O)(C)O)(C)F)C)O)(C)O
isomeric SMILES: CC[C@@H]1[C@@]([C@@H]([C@H](C(=O)[C@@](C[C@@]([C@@H]([C@H]([C@@H]([C@H](C(=O)O1)C)O[C@H]2C[C@@]([C@H]([C@@H](O2)C)O)(C)OC)C)O[C@H]3[C@@H]([C@H](C[C@H](O3)C)N(C)C)O)(C)O)(C)F)C)O)(C)O
World Health Organisation international non-proprietary name: flurithromycin

Sources (2)

via Wikidata · CC0

~1 min read